Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 600MPE | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 13.3 | uM | 12224.147 | 0.4280 | -0.2526 | 0.8621 | |
| 600MPE | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 66.7 | uM | 12224.147 | 0.0122 | -0.9880 | 0.8621 | |
| AU565 | HER2amp | Luminal | Oxamflatin | HDAC | HDAC | 0.000171 | uM | 10880.147 | 0.9563 | 0.9423 | 1.5262 | |
| AU565 | HER2amp | Luminal | Oxamflatin | HDAC | HDAC | 0.000853 | uM | 10880.147 | 1.0571 | 1.0741 | 1.5262 | |
| AU565 | HER2amp | Luminal | Oxamflatin | HDAC | HDAC | 0.00427 | uM | 10880.147 | 0.9615 | 0.9492 | 1.5262 | |
| AU565 | HER2amp | Luminal | Oxamflatin | HDAC | HDAC | 0.0213 | uM | 10880.147 | 0.9915 | 0.9889 | 1.5262 | |
| AU565 | HER2amp | Luminal | Oxamflatin | HDAC | HDAC | 0.107 | uM | 10880.147 | 0.8946 | 0.8593 | 1.5262 | |
| AU565 | HER2amp | Luminal | Oxamflatin | HDAC | HDAC | 0.533 | uM | 10880.147 | 0.7507 | 0.6574 | 1.5262 | |
| AU565 | HER2amp | Luminal | Oxamflatin | HDAC | HDAC | 2.67 | uM | 10880.147 | 0.0840 | -0.6055 | 1.5262 | |
| AU565 | HER2amp | Luminal | Oxamflatin | HDAC | HDAC | 13.3 | uM | 10880.147 | 0.0200 | -0.8460 | 1.5262 | |
| AU565 | HER2amp | Luminal | Oxamflatin | HDAC | HDAC | 66.7 | uM | 10880.147 | 0.0095 | -0.9051 | 1.5262 | |
| BT-20 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 0.000171 | uM | 10581.147 | 1.0488 | 1.0945 | 1.0319 | |
| BT-20 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 0.000853 | uM | 10581.147 | 0.9661 | 0.9342 | 1.0319 | |
| BT-20 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 0.00427 | uM | 10581.147 | 1.0849 | 1.1644 | 1.0319 | |
| BT-20 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 0.0213 | uM | 10581.147 | 1.1047 | 1.2025 | 1.0319 | |
| BT-20 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 0.107 | uM | 10581.147 | 1.0452 | 1.0875 | 1.0319 | |
| BT-20 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 0.533 | uM | 10581.147 | 0.9969 | 0.9940 | 1.0319 | |
| BT-20 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 2.67 | uM | 10581.147 | 0.7641 | 0.5409 | 1.0319 | |
| BT-20 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 13.3 | uM | 10581.147 | 0.3716 | -0.2337 | 1.0319 | |
| BT-20 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 66.7 | uM | 10581.147 | 0.0621 | -0.8647 | 1.0319 | |
| BT-20 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 0.000171 | uM | 11854.147 | 0.9607 | 0.9375 | 1.2634 | |
| BT-20 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 0.000853 | uM | 11854.147 | 1.0034 | 1.0054 | 1.2634 | |
| BT-20 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 0.00427 | uM | 11854.147 | 0.9724 | 0.9561 | 1.2634 | |
| BT-20 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 0.0213 | uM | 11854.147 | 1.0589 | 1.0926 | 1.2634 | |
| BT-20 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 0.107 | uM | 11854.147 | 0.9771 | 0.9636 | 1.2634 |