Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 7527.066 | 0.8727 | 0.8681 | 1.9970 | |
| SK-BR-3 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 7527.066 | 0.3972 | 0.2596 | 1.9970 | |
| SUM1315MO2 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7528.066 | 0.9421 | 0.8870 | 1.0258 | |
| SUM1315MO2 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 7528.066 | 0.9931 | 0.9865 | 1.0258 | |
| SUM1315MO2 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 7528.066 | 0.9527 | 0.9078 | 1.0258 | |
| SUM1315MO2 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 7528.066 | 0.9962 | 0.9927 | 1.0258 | |
| SUM1315MO2 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7528.066 | 1.0578 | 1.1126 | 1.0258 | |
| SUM1315MO2 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7528.066 | 0.9333 | 0.8699 | 1.0258 | |
| SUM1315MO2 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7528.066 | 0.9659 | 0.9335 | 1.0258 | |
| SUM1315MO2 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 7528.066 | 0.8784 | 0.7625 | 1.0258 | |
| SUM1315MO2 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 7528.066 | 0.3291 | -0.3231 | 1.0258 | |
| SUM1315MO2 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 9044.066 | 1.0319 | 1.0749 | 0.8552 | |
| SUM1315MO2 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 9044.066 | 0.9888 | 0.9738 | 0.8552 | |
| SUM1315MO2 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 9044.066 | 1.0368 | 1.0862 | 0.8552 | |
| SUM1315MO2 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 9044.066 | 1.0370 | 1.0868 | 0.8552 | |
| SUM1315MO2 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 9044.066 | 0.9759 | 0.9439 | 0.8552 | |
| SUM1315MO2 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 9044.066 | 1.0061 | 1.0142 | 0.8552 | |
| SUM1315MO2 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 9044.066 | 0.8628 | 0.6831 | 0.8552 | |
| SUM1315MO2 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 9044.066 | 0.8703 | 0.7001 | 0.8552 | |
| SUM1315MO2 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 9044.066 | 0.2435 | -0.6165 | 0.8552 | |
| SUM1315MO2 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 10381.066 | 0.9307 | 0.9033 | 1.4484 | |
| SUM1315MO2 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 10381.066 | 0.9835 | 0.9772 | 1.4484 | |
| SUM1315MO2 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 10381.066 | 0.9770 | 0.9681 | 1.4484 | |
| SUM1315MO2 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 10381.066 | 0.9793 | 0.9713 | 1.4484 | |
| SUM1315MO2 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 10381.066 | 0.9251 | 0.8953 | 1.4484 |