Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MX1 | Unknown | Unknown | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7523.066 | 0.9385 | 0.8498 | 0.8127 | |
| MX1 | Unknown | Unknown | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 7523.066 | 0.9091 | 0.7788 | 0.8127 | |
| MX1 | Unknown | Unknown | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 7523.066 | 0.9456 | 0.8670 | 0.8127 | |
| MX1 | Unknown | Unknown | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 7523.066 | 0.9776 | 0.9449 | 0.8127 | |
| MX1 | Unknown | Unknown | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7523.066 | 0.9294 | 0.8278 | 0.8127 | |
| MX1 | Unknown | Unknown | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7523.066 | 1.0182 | 1.0448 | 0.8127 | |
| MX1 | Unknown | Unknown | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7523.066 | 0.9145 | 0.7917 | 0.8127 | |
| MX1 | Unknown | Unknown | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 7523.066 | 0.8955 | 0.7460 | 0.8127 | |
| MX1 | Unknown | Unknown | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 7523.066 | 0.1622 | -0.7868 | 0.8127 | |
| SK-BR-3 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7526.066 | 0.9637 | 0.9541 | 1.5937 | |
| SK-BR-3 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 7526.066 | 1.0142 | 1.0178 | 1.5937 | |
| SK-BR-3 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 7526.066 | 0.9600 | 0.9494 | 1.5937 | |
| SK-BR-3 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 7526.066 | 1.0137 | 1.0171 | 1.5937 | |
| SK-BR-3 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7526.066 | 1.0706 | 1.0875 | 1.5937 | |
| SK-BR-3 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7526.066 | 0.9763 | 0.9702 | 1.5937 | |
| SK-BR-3 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7526.066 | 0.9671 | 0.9584 | 1.5937 | |
| SK-BR-3 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 7526.066 | 0.9413 | 0.9256 | 1.5937 | |
| SK-BR-3 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 7526.066 | 0.6099 | 0.4665 | 1.5937 | |
| SK-BR-3 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7527.066 | 0.9591 | 0.9586 | 1.9970 | |
| SK-BR-3 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 7527.066 | 0.9862 | 0.9862 | 1.9970 | |
| SK-BR-3 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 7527.066 | 0.9690 | 0.9687 | 1.9970 | |
| SK-BR-3 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 7527.066 | 1.0211 | 1.0210 | 1.9970 | |
| SK-BR-3 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7527.066 | 1.0259 | 1.0257 | 1.9970 | |
| SK-BR-3 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7527.066 | 0.9719 | 0.9717 | 1.9970 | |
| SK-BR-3 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7527.066 | 0.9686 | 0.9683 | 1.9970 |