Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | NM | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7485.066 | 0.9984 | 0.9991 | 3.6205 | |
| MCF 10A | NM | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 7485.066 | 0.9620 | 0.9787 | 3.6205 | |
| MCF 10A | NM | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 7485.066 | 1.0591 | 1.0320 | 3.6205 | |
| MCF 10A | NM | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 7485.066 | 1.0884 | 1.0473 | 3.6205 | |
| MCF 10A | NM | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7485.066 | 1.0526 | 1.0285 | 3.6205 | |
| MCF 10A | NM | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7485.066 | 0.8763 | 0.9284 | 3.6205 | |
| MCF 10A | NM | Basal B | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7485.066 | 0.7241 | 0.8294 | 3.6205 | |
| MCF 10A | NM | Basal B | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 7485.066 | 0.4594 | 0.6133 | 3.6205 | |
| MCF 10A | NM | Basal B | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 7485.066 | 0.0313 | -0.2315 | 3.6205 | |
| MCF 10F | NM | - | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7486.066 | 0.9251 | 0.8564 | 1.0443 | |
| MCF 10F | NM | - | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 7486.066 | 1.0424 | 1.0811 | 1.0443 | |
| MCF 10F | NM | - | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 7486.066 | 0.9678 | 0.9384 | 1.0443 | |
| MCF 10F | NM | - | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 7486.066 | 1.0499 | 1.0955 | 1.0443 | |
| MCF 10F | NM | - | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7486.066 | 1.0008 | 1.0016 | 1.0443 | |
| MCF 10F | NM | - | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7486.066 | 0.9303 | 0.8664 | 1.0443 | |
| MCF 10F | NM | - | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7486.066 | 0.9823 | 0.9660 | 1.0443 | |
| MCF 10F | NM | - | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 7486.066 | 0.9476 | 0.8995 | 1.0443 | |
| MCF 10F | NM | - | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 7486.066 | 0.3460 | -0.2762 | 1.0443 | |
| MCF 10F | NM | - | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7487.066 | 0.9221 | 0.9002 | 1.5845 | |
| MCF 10F | NM | - | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 7487.066 | 0.9905 | 0.9880 | 1.5845 | |
| MCF 10F | NM | - | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 7487.066 | 0.9615 | 0.9510 | 1.5845 | |
| MCF 10F | NM | - | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 7487.066 | 0.9039 | 0.8764 | 1.5845 | |
| MCF 10F | NM | - | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7487.066 | 0.9573 | 0.9457 | 1.5845 | |
| MCF 10F | NM | - | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7487.066 | 0.7282 | 0.6371 | 1.5845 | |
| MCF 10F | NM | - | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7487.066 | 0.5352 | 0.3481 | 1.5845 |