Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1419 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 7440.066 | 0.9902 | 0.9522 | 0.4073 | |
| HCC1419 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7440.066 | 1.0175 | 1.0873 | 0.4073 | |
| HCC1419 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7440.066 | 0.9945 | 0.9732 | 0.4073 | |
| HCC1419 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7440.066 | 1.0100 | 1.0493 | 0.4073 | |
| HCC1419 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 7440.066 | 0.9762 | 0.8851 | 0.4073 | |
| HCC1419 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 7440.066 | 0.8990 | 0.5399 | 0.4073 | |
| HCC1428 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7441.066 | 1.0135 | 1.0356 | 0.7593 | |
| HCC1428 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 7441.066 | 0.9823 | 0.9535 | 0.7593 | |
| HCC1428 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 7441.066 | 1.0162 | 1.0428 | 0.7593 | |
| HCC1428 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 7441.066 | 0.9785 | 0.9435 | 0.7593 | |
| HCC1428 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7441.066 | 1.0410 | 1.1086 | 0.7593 | |
| HCC1428 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7441.066 | 0.9833 | 0.9562 | 0.7593 | |
| HCC1428 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7441.066 | 0.9910 | 0.9763 | 0.7593 | |
| HCC1428 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 7441.066 | 0.8636 | 0.6487 | 0.7593 | |
| HCC1428 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 7441.066 | 0.1826 | -0.7870 | 0.7593 | |
| HCC1428 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7442.066 | 0.9843 | 0.9631 | 0.8481 | |
| HCC1428 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 7442.066 | 0.9886 | 0.9732 | 0.8481 | |
| HCC1428 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 7442.066 | 0.9744 | 0.9399 | 0.8481 | |
| HCC1428 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 7442.066 | 1.0038 | 1.0089 | 0.8481 | |
| HCC1428 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7442.066 | 1.0138 | 1.0326 | 0.8481 | |
| HCC1428 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7442.066 | 0.9525 | 0.8885 | 0.8481 | |
| HCC1428 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7442.066 | 0.9574 | 0.8998 | 0.8481 | |
| HCC1428 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 7442.066 | 0.9291 | 0.8340 | 0.8481 | |
| HCC1428 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 7442.066 | 0.7768 | 0.4848 | 0.8481 | |
| HCC1428 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7443.066 | 0.9496 | 0.8931 | 0.9414 |