Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7435.066 | 0.9041 | 0.7864 | 0.8924 | |
| HCC1395 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7435.066 | 0.9491 | 0.8862 | 0.8924 | |
| HCC1395 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 7435.066 | 0.8793 | 0.7316 | 0.8924 | |
| HCC1395 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 7435.066 | 0.2780 | -0.5236 | 0.8924 | |
| HCC1395 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7436.066 | 0.9810 | 0.9702 | 1.2738 | |
| HCC1395 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 7436.066 | 0.9275 | 0.8853 | 1.2738 | |
| HCC1395 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 7436.066 | 1.0015 | 1.0024 | 1.2738 | |
| HCC1395 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 7436.066 | 1.0031 | 1.0049 | 1.2738 | |
| HCC1395 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7436.066 | 1.0287 | 1.0449 | 1.2738 | |
| HCC1395 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7436.066 | 0.9517 | 0.9237 | 1.2738 | |
| HCC1395 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7436.066 | 0.9212 | 0.8752 | 1.2738 | |
| HCC1395 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 7436.066 | 0.8517 | 0.7633 | 1.2738 | |
| HCC1395 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 7436.066 | 0.0707 | -0.7502 | 1.2738 | |
| HCC1419 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7437.066 | 0.9773 | 0.8738 | 0.3525 | |
| HCC1419 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 7437.066 | 1.0092 | 1.0529 | 0.3525 | |
| HCC1419 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 7437.066 | 1.0036 | 1.0206 | 0.3525 | |
| HCC1419 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 7437.066 | 0.9818 | 0.8982 | 0.3525 | |
| HCC1419 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7437.066 | 1.0393 | 1.2314 | 0.3525 | |
| HCC1419 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7437.066 | 1.0021 | 1.0121 | 0.3525 | |
| HCC1419 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7437.066 | 1.0020 | 1.0111 | 0.3525 | |
| HCC1419 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 7437.066 | 0.9349 | 0.6525 | 0.3525 | |
| HCC1419 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 7437.066 | 0.8025 | 0.0714 | 0.3525 | |
| HCC1419 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7440.066 | 1.0211 | 1.1053 | 0.4073 | |
| HCC1419 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 7440.066 | 0.9737 | 0.8733 | 0.4073 | |
| HCC1419 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 7440.066 | 0.9723 | 0.8668 | 0.4073 |