Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1187 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 7431.066 | 0.8129 | 0.6796 | 1.1865 | |
| HCC1187 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 7431.066 | 0.4235 | -0.0306 | 1.1865 | |
| HCC1187 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7432.066 | 0.9731 | 0.9461 | 0.9987 | |
| HCC1187 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 7432.066 | 1.0347 | 1.0695 | 0.9987 | |
| HCC1187 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 7432.066 | 1.0960 | 1.1922 | 0.9987 | |
| HCC1187 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 7432.066 | 0.9603 | 0.9205 | 0.9987 | |
| HCC1187 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7432.066 | 1.0441 | 1.0883 | 0.9987 | |
| HCC1187 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7432.066 | 1.0137 | 1.0273 | 0.9987 | |
| HCC1187 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7432.066 | 0.9107 | 0.8211 | 0.9987 | |
| HCC1187 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 7432.066 | 0.8357 | 0.6709 | 0.9987 | |
| HCC1187 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 7432.066 | 0.0381 | -0.9242 | 0.9987 | |
| HCC1187 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7433.066 | 0.9938 | 0.9884 | 1.0755 | |
| HCC1187 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 7433.066 | 1.0262 | 1.0486 | 1.0755 | |
| HCC1187 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 7433.066 | 1.0185 | 1.0344 | 1.0755 | |
| HCC1187 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 7433.066 | 1.0225 | 1.0417 | 1.0755 | |
| HCC1187 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7433.066 | 1.0541 | 1.1004 | 1.0755 | |
| HCC1187 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7433.066 | 0.9861 | 0.9742 | 1.0755 | |
| HCC1187 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7433.066 | 1.0185 | 1.0344 | 1.0755 | |
| HCC1187 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 7433.066 | 0.8830 | 0.7815 | 1.0755 | |
| HCC1187 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 7433.066 | 0.1656 | -0.6242 | 1.0755 | |
| HCC1395 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7435.066 | 0.9494 | 0.8869 | 0.8924 | |
| HCC1395 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 7435.066 | 0.8923 | 0.7602 | 0.8924 | |
| HCC1395 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 7435.066 | 0.8871 | 0.7487 | 0.8924 | |
| HCC1395 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 7435.066 | 1.0076 | 1.0171 | 0.8924 | |
| HCC1395 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7435.066 | 1.0245 | 1.0550 | 0.8924 |