Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 12003.135 | 0.8652 | 0.7279 | 0.9898 | |
| ZR-75-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 12003.135 | 0.7065 | 0.4079 | 0.9898 | |
| ZR-75-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 12003.135 | 0.7007 | 0.3962 | 0.9898 | |
| ZR-75-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 12003.135 | 0.6741 | 0.3427 | 0.9898 | |
| ZR-75-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 12003.135 | 0.5999 | 0.1934 | 0.9898 | |
| ZR75B | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 11939.135 | 0.8719 | 0.8356 | 1.5987 | |
| ZR75B | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 11939.135 | 0.9367 | 0.9198 | 1.5987 | |
| ZR75B | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 11939.135 | 1.0281 | 1.0350 | 1.5987 | |
| ZR75B | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 11939.135 | 1.0430 | 1.0534 | 1.5987 | |
| ZR75B | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 11939.135 | 0.8507 | 0.8076 | 1.5987 | |
| ZR75B | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 11939.135 | 0.6270 | 0.4936 | 1.5987 | |
| ZR75B | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 11939.135 | 0.6180 | 0.4801 | 1.5987 | |
| ZR75B | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 11939.135 | 0.5901 | 0.4380 | 1.5987 | |
| ZR75B | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 11939.135 | 0.7580 | 0.6818 | 1.5987 | |
| 184A1 | NM | Basal | Nelfinavir | 0.0000853 | uM | 12684.174 | 1.0639 | 1.0864 | 1.4645 | |||
| 184A1 | NM | Basal | Nelfinavir | 0.000427 | uM | 12684.174 | 1.0625 | 1.0845 | 1.4645 | |||
| 184A1 | NM | Basal | Nelfinavir | 0.00213 | uM | 12684.174 | 0.9275 | 0.8999 | 1.4645 | |||
| 184A1 | NM | Basal | Nelfinavir | 0.0107 | uM | 12684.174 | 0.9813 | 0.9744 | 1.4645 | |||
| 184A1 | NM | Basal | Nelfinavir | 0.0533 | uM | 12684.174 | 0.9928 | 0.9901 | 1.4645 | |||
| 184A1 | NM | Basal | Nelfinavir | 0.267 | uM | 12684.174 | 0.8747 | 0.8253 | 1.4645 | |||
| 184A1 | NM | Basal | Nelfinavir | 1.33 | uM | 12684.174 | 0.9426 | 0.9209 | 1.4645 | |||
| 184A1 | NM | Basal | Nelfinavir | 6.67 | uM | 12684.174 | 0.2352 | -0.2556 | 1.4645 | |||
| 184A1 | NM | Basal | Nelfinavir | 33.3 | uM | 12684.174 | 0.0797 | -0.6445 | 1.4645 | |||
| 184B5 | NM | Basal | Nelfinavir | 0.0000853 | uM | 12979.174 | 1.1474 | 1.1832 | 1.5680 | |||
| 184B5 | NM | Basal | Nelfinavir | 0.000427 | uM | 12979.174 | 1.0613 | 1.0773 | 1.5680 |