Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-175-VII | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 12126.135 | 0.5721 | -0.0946 | 0.7048 | |
| MDA-MB-175-VII | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 12126.135 | 0.5800 | -0.0767 | 0.7048 | |
| MDA-MB-175-VII | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 12126.135 | 0.5245 | -0.1996 | 0.7048 | |
| MDA-MB-361 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 10999.135 | 1.0265 | 1.1105 | 0.4857 | |
| MDA-MB-361 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 10999.135 | 1.0073 | 1.0303 | 0.4857 | |
| MDA-MB-361 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 10999.135 | 1.0053 | 1.0218 | 0.4857 | |
| MDA-MB-361 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 10999.135 | 1.0326 | 1.1368 | 0.4857 | |
| MDA-MB-361 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 10999.135 | 0.7206 | 0.0187 | 0.4857 | |
| MDA-MB-361 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 10999.135 | 0.4330 | -0.6430 | 0.4857 | |
| MDA-MB-361 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 10999.135 | 0.4030 | -0.6921 | 0.4857 | |
| MDA-MB-361 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 10999.135 | 0.3552 | -0.7626 | 0.4857 | |
| MDA-MB-361 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 10999.135 | 0.3529 | -0.7657 | 0.4857 | |
| MDA-MB-361 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 12379.135 | 0.9727 | 0.8915 | 0.4972 | |
| MDA-MB-361 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 12379.135 | 1.0161 | 1.0654 | 0.4972 | |
| MDA-MB-361 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 12379.135 | 1.0381 | 1.1564 | 0.4972 | |
| MDA-MB-361 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 12379.135 | 1.0258 | 1.1051 | 0.4972 | |
| MDA-MB-361 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 12379.135 | 0.9332 | 0.7402 | 0.4972 | |
| MDA-MB-361 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 12379.135 | 0.6640 | -0.1222 | 0.4972 | |
| MDA-MB-361 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 12379.135 | 0.4669 | -0.5677 | 0.4972 | |
| MDA-MB-361 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 12379.135 | 0.4194 | -0.6517 | 0.4972 | |
| MDA-MB-361 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 12379.135 | 0.3964 | -0.6890 | 0.4972 | |
| MDA-MB-415 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 10938.148 | 0.8515 | 0.7016 | 0.9949 | |
| MDA-MB-415 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 10938.148 | 0.7791 | 0.5563 | 0.9949 | |
| MDA-MB-415 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 10938.148 | 0.8926 | 0.7841 | 0.9949 | |
| MDA-MB-415 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 10938.148 | 0.8283 | 0.6550 | 0.9949 |