Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-415 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 10938.148 | 0.7376 | 0.4729 | 0.9949 | |
| MDA-MB-415 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 10938.148 | 0.6291 | 0.2552 | 0.9949 | |
| MDA-MB-415 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 10938.148 | 0.5832 | 0.1632 | 0.9949 | |
| MDA-MB-415 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 10938.148 | 0.4578 | -0.0880 | 0.9949 | |
| MDA-MB-415 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 10938.148 | 0.4852 | -0.0333 | 0.9949 | |
| MDA-MB-415 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 12333.135 | 0.9868 | 0.9391 | 0.4305 | |
| MDA-MB-415 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 12333.135 | 0.9736 | 0.8793 | 0.4305 | |
| MDA-MB-415 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 12333.135 | 0.9891 | 0.9496 | 0.4305 | |
| MDA-MB-415 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 12333.135 | 1.0770 | 1.3762 | 0.4305 | |
| MDA-MB-415 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 12333.135 | 0.9253 | 0.6698 | 0.4305 | |
| MDA-MB-415 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 12333.135 | 0.4883 | -0.6217 | 0.4305 | |
| MDA-MB-415 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 12333.135 | 0.2981 | -0.8798 | 0.4305 | |
| MDA-MB-415 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 12333.135 | 0.2470 | -0.9223 | 0.4305 | |
| MDA-MB-415 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 12333.135 | 0.2252 | -0.9374 | 0.4305 | |
| MDA-MB-453 | TNBC | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 12414.135 | 0.9414 | 0.9008 | 1.1872 | |
| MDA-MB-453 | TNBC | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 12414.135 | 0.9777 | 0.9623 | 1.1872 | |
| MDA-MB-453 | TNBC | Luminal | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 12414.135 | 1.0394 | 1.0663 | 1.1872 | |
| MDA-MB-453 | TNBC | Luminal | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 12414.135 | 1.0197 | 1.0331 | 1.1872 | |
| MDA-MB-453 | TNBC | Luminal | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 12414.135 | 0.9996 | 0.9993 | 1.1872 | |
| MDA-MB-453 | TNBC | Luminal | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 12414.135 | 0.8053 | 0.6665 | 1.1872 | |
| MDA-MB-453 | TNBC | Luminal | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 12414.135 | 0.6554 | 0.4010 | 1.1872 | |
| MDA-MB-453 | TNBC | Luminal | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 12414.135 | 0.4362 | -0.0057 | 1.1872 | |
| MDA-MB-453 | TNBC | Luminal | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 12414.135 | 0.4474 | 0.0157 | 1.1872 | |
| MX1 | Unknown | Unknown | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 10644.135 | 0.9591 | 0.8476 | 0.5273 | |
| MX1 | Unknown | Unknown | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 10644.135 | 0.9096 | 0.6710 | 0.5273 |