Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-157 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 12594.135 | 0.2124 | -0.3682 | 1.3446 | |
| MDA-MB-175-VII | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 10642.135 | 0.9584 | 0.7721 | 0.3509 | |
| MDA-MB-175-VII | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 10642.135 | 0.9449 | 0.7019 | 0.3509 | |
| MDA-MB-175-VII | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 10642.135 | 0.9567 | 0.7628 | 0.3509 | |
| MDA-MB-175-VII | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 10642.135 | 0.9734 | 0.8523 | 0.3509 | |
| MDA-MB-175-VII | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 10642.135 | 0.9248 | 0.6007 | 0.3509 | |
| MDA-MB-175-VII | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 10642.135 | 0.7929 | 0.0323 | 0.3509 | |
| MDA-MB-175-VII | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 10642.135 | 0.5305 | -0.6716 | 0.3509 | |
| MDA-MB-175-VII | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 10642.135 | 0.5377 | -0.6588 | 0.3509 | |
| MDA-MB-175-VII | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 10642.135 | 0.3536 | -0.8966 | 0.3509 | |
| MDA-MB-175-VII | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 10818.148 | 0.9830 | 0.9053 | 0.3526 | |
| MDA-MB-175-VII | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 10818.148 | 0.9763 | 0.8683 | 0.3526 | |
| MDA-MB-175-VII | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 10818.148 | 1.0022 | 1.0127 | 0.3526 | |
| MDA-MB-175-VII | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 10818.148 | 1.0391 | 1.2295 | 0.3526 | |
| MDA-MB-175-VII | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 10818.148 | 0.9830 | 0.9053 | 0.3526 | |
| MDA-MB-175-VII | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 10818.148 | 0.7514 | -0.1108 | 0.3526 | |
| MDA-MB-175-VII | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 10818.148 | 0.5965 | -0.5380 | 0.3526 | |
| MDA-MB-175-VII | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 10818.148 | 0.5692 | -0.5955 | 0.3526 | |
| MDA-MB-175-VII | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 10818.148 | 0.4426 | -0.8018 | 0.3526 | |
| MDA-MB-175-VII | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 12126.135 | 0.9261 | 0.7937 | 0.7048 | |
| MDA-MB-175-VII | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 12126.135 | 0.9423 | 0.8383 | 0.7048 | |
| MDA-MB-175-VII | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 12126.135 | 0.9507 | 0.8616 | 0.7048 | |
| MDA-MB-175-VII | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 12126.135 | 0.9500 | 0.8596 | 0.7048 | |
| MDA-MB-175-VII | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 12126.135 | 0.9365 | 0.8221 | 0.7048 | |
| MDA-MB-175-VII | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 12126.135 | 0.7575 | 0.3487 | 0.7048 |