Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 11936.135 | 0.5841 | 0.0690 | 0.8584 | |
| HCC1569 | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 10872.148 | 0.9009 | 0.8669 | 1.5151 | |
| HCC1569 | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 10872.148 | 1.0057 | 1.0075 | 1.5151 | |
| HCC1569 | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 10872.148 | 0.8690 | 0.8229 | 1.5151 | |
| HCC1569 | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 10872.148 | 0.7251 | 0.6176 | 1.5151 | |
| HCC1569 | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 10872.148 | 0.8223 | 0.7577 | 1.5151 | |
| HCC1569 | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 10872.148 | 0.9472 | 0.9296 | 1.5151 | |
| HCC1569 | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 10872.148 | 0.9855 | 0.9808 | 1.5151 | |
| HCC1569 | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 10872.148 | 0.9542 | 0.9391 | 1.5151 | |
| HCC1569 | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 10872.148 | 1.0512 | 1.0670 | 1.5151 | |
| HCC1569 | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 12523.135 | 0.9897 | 0.9769 | 0.8958 | |
| HCC1569 | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 12523.135 | 1.0153 | 1.0342 | 0.8958 | |
| HCC1569 | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 12523.135 | 1.0469 | 1.1049 | 0.8958 | |
| HCC1569 | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 12523.135 | 1.0197 | 1.0441 | 0.8958 | |
| HCC1569 | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 12523.135 | 0.8689 | 0.7097 | 0.8958 | |
| HCC1569 | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 12523.135 | 0.7931 | 0.5440 | 0.8958 | |
| HCC1569 | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 12523.135 | 0.8081 | 0.5766 | 0.8958 | |
| HCC1569 | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 12523.135 | 0.7042 | 0.3522 | 0.8958 | |
| HCC1569 | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 12523.135 | 0.6130 | 0.1582 | 0.8958 | |
| HCC1806 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 12239.135 | 1.0346 | 1.0329 | 2.0860 | |
| HCC1806 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 12239.135 | 0.9440 | 0.9455 | 2.0860 | |
| HCC1806 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 12239.135 | 0.9289 | 0.9305 | 2.0860 | |
| HCC1806 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 12239.135 | 0.5834 | 0.5447 | 2.0860 | |
| HCC1806 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 12239.135 | 0.2557 | 0.0401 | 2.0860 | |
| HCC1806 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 12239.135 | 0.1514 | -0.1908 | 2.0860 |