Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-812 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 10754.148 | 0.5198 | 0.1270 | 1.1406 | |
| UACC-812 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 10754.148 | 0.3243 | -0.2548 | 1.1406 | |
| UACC-812 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 10754.148 | 0.2923 | -0.3197 | 1.1406 | |
| UACC-812 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 11938.135 | 0.8929 | 0.6953 | 0.6853 | |
| UACC-812 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 11938.135 | 0.8765 | 0.6500 | 0.6853 | |
| UACC-812 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 11938.135 | 0.9199 | 0.7707 | 0.6853 | |
| UACC-812 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 11938.135 | 0.9511 | 0.8589 | 0.6853 | |
| UACC-812 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 11938.135 | 0.9063 | 0.7325 | 0.6853 | |
| UACC-812 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 11938.135 | 0.8593 | 0.6030 | 0.6853 | |
| UACC-812 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 11938.135 | 0.6466 | 0.0586 | 0.6853 | |
| UACC-812 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 11938.135 | 0.4112 | -0.4532 | 0.6853 | |
| UACC-812 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 11938.135 | 0.5688 | -0.1221 | 0.6853 | |
| ZR-75-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 11660.148 | 0.9049 | 0.8333 | 1.1480 | |
| ZR-75-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 11660.148 | 0.9052 | 0.8338 | 1.1480 | |
| ZR-75-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 11660.148 | 0.9590 | 0.9284 | 1.1480 | |
| ZR-75-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 11660.148 | 0.9483 | 0.9097 | 1.1480 | |
| ZR-75-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 11660.148 | 0.9474 | 0.9080 | 1.1480 | |
| ZR-75-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 11660.148 | 0.8261 | 0.6934 | 1.1480 | |
| ZR-75-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 11660.148 | 0.7127 | 0.4889 | 1.1480 | |
| ZR-75-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 11660.148 | 0.7514 | 0.5593 | 1.1480 | |
| ZR-75-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 11660.148 | 0.7325 | 0.5250 | 1.1480 | |
| ZR-75-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 12003.135 | 0.9399 | 0.8786 | 0.9898 | |
| ZR-75-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 12003.135 | 0.9175 | 0.8333 | 0.9898 | |
| ZR-75-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 12003.135 | 0.9399 | 0.8786 | 0.9898 | |
| ZR-75-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 12003.135 | 0.9376 | 0.8739 | 0.9898 |