Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T47D | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 10939.148 | 0.5098 | 0.3318 | 1.6568 | |
| T47DKBLUC | Unknown | Unknown | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 12608.135 | 0.9412 | 0.9047 | 1.2417 | |
| T47DKBLUC | Unknown | Unknown | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 12608.135 | 0.9521 | 0.9226 | 1.2417 | |
| T47DKBLUC | Unknown | Unknown | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 12608.135 | 0.9758 | 0.9609 | 1.2417 | |
| T47DKBLUC | Unknown | Unknown | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 12608.135 | 0.9559 | 0.9287 | 1.2417 | |
| T47DKBLUC | Unknown | Unknown | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 12608.135 | 0.8926 | 0.8251 | 1.2417 | |
| T47DKBLUC | Unknown | Unknown | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 12608.135 | 0.4516 | 0.0543 | 1.2417 | |
| T47DKBLUC | Unknown | Unknown | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 12608.135 | 0.5108 | 0.1643 | 1.2417 | |
| T47DKBLUC | Unknown | Unknown | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 12608.135 | 0.5348 | 0.2081 | 1.2417 | |
| T47DKBLUC | Unknown | Unknown | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 12608.135 | 0.5414 | 0.2203 | 1.2417 | |
| UACC-812 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 10580.135 | 0.9044 | 0.8065 | 0.9868 | |
| UACC-812 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 10580.135 | 0.9142 | 0.8262 | 0.9868 | |
| UACC-812 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 10580.135 | 0.8814 | 0.7599 | 0.9868 | |
| UACC-812 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 10580.135 | 0.9268 | 0.8518 | 0.9868 | |
| UACC-812 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 10580.135 | 0.9339 | 0.8661 | 0.9868 | |
| UACC-812 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 10580.135 | 0.8905 | 0.7782 | 0.9868 | |
| UACC-812 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 10580.135 | 0.6972 | 0.3876 | 0.9868 | |
| UACC-812 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 10580.135 | 0.5067 | 0.0042 | 0.9868 | |
| UACC-812 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 10580.135 | 0.5018 | -0.0056 | 0.9868 | |
| UACC-812 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 10754.148 | 0.9660 | 0.9403 | 1.1406 | |
| UACC-812 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 10754.148 | 0.9833 | 0.9706 | 1.1406 | |
| UACC-812 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 10754.148 | 0.9222 | 0.8629 | 1.1406 | |
| UACC-812 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 10754.148 | 0.9769 | 0.9594 | 1.1406 | |
| UACC-812 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 10754.148 | 1.0596 | 1.1041 | 1.1406 | |
| UACC-812 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 10754.148 | 0.7877 | 0.6225 | 1.1406 |