Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM52PE | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 10695.148 | 0.8814 | 0.8393 | 1.5078 | |
| SUM52PE | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 10695.148 | 0.8291 | 0.7663 | 1.5078 | |
| SUM52PE | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 10695.148 | 0.8500 | 0.7957 | 1.5078 | |
| SUM52PE | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 10695.148 | 0.7461 | 0.6470 | 1.5078 | |
| SUM52PE | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 10695.148 | 0.6619 | 0.5211 | 1.5078 | |
| SUM52PE | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 10695.148 | 0.3823 | 0.0570 | 1.5078 | |
| SUM52PE | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 10695.148 | 0.3737 | 0.0411 | 1.5078 | |
| SUM52PE | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 10695.148 | 0.3865 | 0.0648 | 1.5078 | |
| SUM52PE | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 11852.135 | 1.0365 | 1.0583 | 1.2467 | |
| SUM52PE | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 11852.135 | 1.1261 | 1.1999 | 1.2467 | |
| SUM52PE | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 11852.135 | 1.0037 | 1.0060 | 1.2467 | |
| SUM52PE | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 11852.135 | 1.0405 | 1.0647 | 1.2467 | |
| SUM52PE | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 11852.135 | 0.9972 | 0.9955 | 1.2467 | |
| SUM52PE | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 11852.135 | 0.6852 | 0.4768 | 1.2467 | |
| SUM52PE | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 11852.135 | 0.3156 | -0.2070 | 1.2467 | |
| SUM52PE | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 11852.135 | 0.2164 | -0.4142 | 1.2467 | |
| SUM52PE | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 11852.135 | 0.3255 | -0.1871 | 1.2467 | |
| T47D | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 10939.148 | 0.9343 | 0.9197 | 1.6568 | |
| T47D | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 10939.148 | 0.9455 | 0.9335 | 1.6568 | |
| T47D | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 10939.148 | 0.9908 | 0.9889 | 1.6568 | |
| T47D | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 10939.148 | 0.9895 | 0.9873 | 1.6568 | |
| T47D | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 10939.148 | 0.7640 | 0.7001 | 1.6568 | |
| T47D | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 10939.148 | 0.4648 | 0.2596 | 1.6568 | |
| T47D | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 10939.148 | 0.5612 | 0.4112 | 1.6568 | |
| T47D | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 10939.148 | 0.5295 | 0.3625 | 1.6568 |