Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM225CWN | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 10579.135 | 0.9870 | 0.9670 | 0.7853 | |
| SUM225CWN | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 10579.135 | 1.0705 | 1.1811 | 0.7853 | |
| SUM225CWN | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 10579.135 | 1.0017 | 1.0043 | 0.7853 | |
| SUM225CWN | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 10579.135 | 0.8423 | 0.6074 | 0.7853 | |
| SUM225CWN | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 10579.135 | 0.6142 | 0.0752 | 0.7853 | |
| SUM225CWN | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 10579.135 | 0.3416 | -0.4907 | 0.7853 | |
| SUM225CWN | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 12098.135 | 0.9641 | 0.9438 | 1.2823 | |
| SUM225CWN | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 12098.135 | 0.9918 | 0.9872 | 1.2823 | |
| SUM225CWN | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 12098.135 | 0.9935 | 0.9899 | 1.2823 | |
| SUM225CWN | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 12098.135 | 1.0282 | 1.0439 | 1.2823 | |
| SUM225CWN | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 12098.135 | 1.0737 | 1.1140 | 1.2823 | |
| SUM225CWN | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 12098.135 | 0.8744 | 0.8012 | 1.2823 | |
| SUM225CWN | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 12098.135 | 0.8145 | 0.7043 | 1.2823 | |
| SUM225CWN | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 12098.135 | 0.4641 | 0.0991 | 1.2823 | |
| SUM225CWN | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 12098.135 | 0.2656 | -0.2888 | 1.2823 | |
| SUM229PE | TNBC | - | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 11058.135 | 0.9100 | 0.9141 | 2.1492 | |
| SUM229PE | TNBC | - | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 11058.135 | 0.9631 | 0.9653 | 2.1492 | |
| SUM229PE | TNBC | - | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 11058.135 | 0.9798 | 0.9811 | 2.1492 | |
| SUM229PE | TNBC | - | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 11058.135 | 1.0348 | 1.0321 | 2.1492 | |
| SUM229PE | TNBC | - | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 11058.135 | 0.7945 | 0.7970 | 2.1492 | |
| SUM229PE | TNBC | - | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 11058.135 | 0.3948 | 0.2979 | 2.1492 | |
| SUM229PE | TNBC | - | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 11058.135 | 0.2955 | 0.1342 | 2.1492 | |
| SUM229PE | TNBC | - | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 11058.135 | 0.2623 | 0.0730 | 2.1492 | |
| SUM229PE | TNBC | - | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 11058.135 | 0.2202 | -0.0109 | 2.1492 | |
| SUM52PE | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 10695.148 | 0.8691 | 0.8223 | 1.5078 |