Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF12A | NM | Basal B | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 12365.135 | 0.7225 | 0.7273 | 2.2181 | |
| MCF12A | NM | Basal B | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 12365.135 | 0.4860 | 0.4447 | 2.2181 | |
| MCF12A | NM | Basal B | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 12365.135 | 0.2912 | 0.1467 | 2.2181 | |
| MCF12A | NM | Basal B | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 12365.135 | 0.1727 | -0.0940 | 2.2181 | |
| MCF12A | NM | Basal B | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 12365.135 | 0.1542 | -0.1391 | 2.2181 | |
| MCF12A | NM | Basal B | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 12365.135 | 0.1338 | -0.1925 | 2.2181 | |
| MCF7 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 10997.135 | 0.9510 | 0.8529 | 0.6582 | |
| MCF7 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 10997.135 | 0.9682 | 0.9043 | 0.6582 | |
| MCF7 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 10997.135 | 0.9820 | 0.9455 | 0.6582 | |
| MCF7 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 10997.135 | 0.9277 | 0.7844 | 0.6582 | |
| MCF7 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 10997.135 | 0.7389 | 0.2628 | 0.6582 | |
| MCF7 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 10997.135 | 0.5591 | -0.1732 | 0.6582 | |
| MCF7 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 10997.135 | 0.3058 | -0.6695 | 0.6582 | |
| MCF7 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 10997.135 | 0.2333 | -0.7808 | 0.6582 | |
| MCF7 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 10997.135 | 0.2004 | -0.8261 | 0.6582 | |
| MDA-MB-134-VI | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 10519.135 | 0.9818 | 0.9592 | 0.8926 | |
| MDA-MB-134-VI | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 10519.135 | 0.9905 | 0.9786 | 0.8926 | |
| MDA-MB-134-VI | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 10519.135 | 1.0149 | 1.0334 | 0.8926 | |
| MDA-MB-134-VI | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 10519.135 | 0.9650 | 0.9217 | 0.8926 | |
| MDA-MB-134-VI | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 10519.135 | 0.8166 | 0.5939 | 0.8926 | |
| MDA-MB-134-VI | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 10519.135 | 0.5194 | -0.0400 | 0.8926 | |
| MDA-MB-134-VI | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 10519.135 | 0.4101 | -0.2632 | 0.8926 | |
| MDA-MB-134-VI | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 10519.135 | 0.3373 | -0.4080 | 0.8926 | |
| MDA-MB-134-VI | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 10519.135 | 0.3620 | -0.3593 | 0.8926 | |
| MDA-MB-134-VI | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 10998.135 | 0.9448 | 0.7927 | 0.5194 |