Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-134-VI | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 10998.135 | 0.9728 | 0.8964 | 0.5194 | |
| MDA-MB-134-VI | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 10998.135 | 0.9858 | 0.9457 | 0.5194 | |
| MDA-MB-134-VI | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 10998.135 | 0.8415 | 0.4346 | 0.5194 | |
| MDA-MB-134-VI | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 10998.135 | 0.6684 | -0.0792 | 0.5194 | |
| MDA-MB-134-VI | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 10998.135 | 0.4836 | -0.5063 | 0.5194 | |
| MDA-MB-134-VI | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 10998.135 | 0.3706 | -0.7043 | 0.5194 | |
| MDA-MB-134-VI | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 10998.135 | 0.3293 | -0.7644 | 0.5194 | |
| MDA-MB-134-VI | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 10998.135 | 0.3352 | -0.7562 | 0.5194 | |
| MDA-MB-134-VI | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 12206.135 | 1.0463 | 1.0939 | 0.9865 | |
| MDA-MB-134-VI | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 12206.135 | 0.9937 | 0.9872 | 0.9865 | |
| MDA-MB-134-VI | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 12206.135 | 0.9781 | 0.9557 | 0.9865 | |
| MDA-MB-134-VI | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 12206.135 | 0.9031 | 0.8038 | 0.9865 | |
| MDA-MB-134-VI | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 12206.135 | 0.7105 | 0.4143 | 0.9865 | |
| MDA-MB-134-VI | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 12206.135 | 0.5036 | -0.0023 | 0.9865 | |
| MDA-MB-134-VI | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 12206.135 | 0.3865 | -0.2370 | 0.9865 | |
| MDA-MB-134-VI | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 12206.135 | 0.3438 | -0.3224 | 0.9865 | |
| MDA-MB-134-VI | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 12206.135 | 0.3876 | -0.2349 | 0.9865 | |
| MDA-MB-157 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 12594.135 | 0.9454 | 0.9183 | 1.3446 | |
| MDA-MB-157 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 12594.135 | 0.9546 | 0.9321 | 1.3446 | |
| MDA-MB-157 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 12594.135 | 0.9549 | 0.9326 | 1.3446 | |
| MDA-MB-157 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 12594.135 | 0.8355 | 0.7497 | 1.3446 | |
| MDA-MB-157 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 12594.135 | 0.5500 | 0.2821 | 1.3446 | |
| MDA-MB-157 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 12594.135 | 0.4159 | 0.0416 | 1.3446 | |
| MDA-MB-157 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 12594.135 | 0.3424 | -0.0987 | 1.3446 | |
| MDA-MB-157 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 12594.135 | 0.2284 | -0.3331 | 1.3446 |