Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAMA-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 12070.135 | 0.3669 | -0.1057 | 1.2457 | |
| CAMA-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 12070.135 | 0.4534 | 0.0600 | 1.2457 | |
| CAMA-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 12070.135 | 0.3753 | -0.0895 | 1.2457 | |
| CAMA-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 12070.135 | 0.4607 | 0.0735 | 1.2457 | |
| HCC1143 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 12112.135 | 0.9191 | 0.9093 | 1.8185 | |
| HCC1143 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 12112.135 | 0.9112 | 0.9002 | 1.8185 | |
| HCC1143 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 12112.135 | 0.9494 | 0.9437 | 1.8185 | |
| HCC1143 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 12112.135 | 0.8180 | 0.7908 | 1.8185 | |
| HCC1143 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 12112.135 | 0.7401 | 0.6949 | 1.8185 | |
| HCC1143 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 12112.135 | 0.5559 | 0.4481 | 1.8185 | |
| HCC1143 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 12112.135 | 0.3650 | 0.1490 | 1.8185 | |
| HCC1143 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 12112.135 | 0.2545 | -0.0576 | 1.8185 | |
| HCC1143 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 12112.135 | 0.2042 | -0.1652 | 1.8185 | |
| HCC1187 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 10518.135 | 0.9237 | 0.8661 | 1.1446 | |
| HCC1187 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 10518.135 | 0.9976 | 0.9957 | 1.1446 | |
| HCC1187 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 10518.135 | 0.9884 | 0.9796 | 1.1446 | |
| HCC1187 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 10518.135 | 0.9592 | 0.9285 | 1.1446 | |
| HCC1187 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 10518.135 | 1.0005 | 1.0009 | 1.1446 | |
| HCC1187 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 10518.135 | 0.8774 | 0.7840 | 1.1446 | |
| HCC1187 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 10518.135 | 0.5385 | 0.1646 | 1.1446 | |
| HCC1187 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 10518.135 | 0.3898 | -0.1218 | 1.1446 | |
| HCC1187 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 10518.135 | 0.4373 | -0.0291 | 1.1446 | |
| HCC1187 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 10753.148 | 0.9280 | 0.8882 | 1.2988 | |
| HCC1187 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 10753.148 | 0.9194 | 0.8748 | 1.2988 | |
| HCC1187 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 10753.148 | 0.9338 | 0.8973 | 1.2988 |