Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1187 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 10753.148 | 1.0020 | 1.0031 | 1.2988 | |
| HCC1187 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 10753.148 | 1.0082 | 1.0125 | 1.2988 | |
| HCC1187 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 10753.148 | 0.6074 | 0.3625 | 1.2988 | |
| HCC1187 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 10753.148 | 0.4402 | 0.0633 | 1.2988 | |
| HCC1187 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 10753.148 | 0.3029 | -0.2026 | 1.2988 | |
| HCC1187 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 10753.148 | 0.3057 | -0.1970 | 1.2988 | |
| HCC1395 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 12000.135 | 0.9677 | 0.9073 | 0.6914 | |
| HCC1395 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 12000.135 | 0.9845 | 0.9554 | 0.6914 | |
| HCC1395 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 12000.135 | 0.9808 | 0.9447 | 0.6914 | |
| HCC1395 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 12000.135 | 0.9050 | 0.7311 | 0.6914 | |
| HCC1395 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 12000.135 | 0.9088 | 0.7417 | 0.6914 | |
| HCC1395 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 12000.135 | 0.8970 | 0.7091 | 0.6914 | |
| HCC1395 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 12000.135 | 0.8336 | 0.5370 | 0.6914 | |
| HCC1395 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 12000.135 | 0.7539 | 0.3291 | 0.6914 | |
| HCC1395 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 12000.135 | 0.6078 | -0.0266 | 0.6914 | |
| HCC1395 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 12084.135 | 0.9580 | 0.9403 | 1.4162 | |
| HCC1395 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 12084.135 | 0.9516 | 0.9312 | 1.4162 | |
| HCC1395 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 12084.135 | 0.8730 | 0.8171 | 1.4162 | |
| HCC1395 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 12084.135 | 0.8538 | 0.7889 | 1.4162 | |
| HCC1395 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 12084.135 | 0.8815 | 0.8295 | 1.4162 | |
| HCC1395 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 12084.135 | 0.6625 | 0.4954 | 1.4162 | |
| HCC1395 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 12084.135 | 0.6535 | 0.4810 | 1.4162 | |
| HCC1395 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 12084.135 | 0.4595 | 0.1549 | 1.4162 | |
| HCC1395 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 12084.135 | 0.3744 | -0.0005 | 1.4162 | |
| HCC1419 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 12001.135 | 0.9801 | 0.9114 | 0.4442 |