Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1419 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 12001.135 | 0.9684 | 0.8607 | 0.4442 | |
| HCC1419 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 12001.135 | 0.9702 | 0.8681 | 0.4442 | |
| HCC1419 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 12001.135 | 0.9120 | 0.6254 | 0.4442 | |
| HCC1419 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 12001.135 | 0.9091 | 0.6138 | 0.4442 | |
| HCC1419 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 12001.135 | 0.7092 | -0.0772 | 0.4442 | |
| HCC1419 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 12001.135 | 0.3422 | -0.8211 | 0.4442 | |
| HCC1419 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 12001.135 | 0.3747 | -0.7806 | 0.4442 | |
| HCC1419 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 12001.135 | 0.4113 | -0.7293 | 0.4442 | |
| HCC1428 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 10693.148 | 0.9507 | 0.8905 | 0.8983 | |
| HCC1428 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 10693.148 | 0.9747 | 0.9438 | 0.8983 | |
| HCC1428 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 10693.148 | 0.9475 | 0.8834 | 0.8983 | |
| HCC1428 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 10693.148 | 0.9260 | 0.8359 | 0.8983 | |
| HCC1428 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 10693.148 | 0.7888 | 0.5358 | 0.8983 | |
| HCC1428 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 10693.148 | 0.6546 | 0.2479 | 0.8983 | |
| HCC1428 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 10693.148 | 0.6615 | 0.2625 | 0.8983 | |
| HCC1428 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 10693.148 | 0.6722 | 0.2853 | 0.8983 | |
| HCC1428 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 10693.148 | 0.6075 | 0.1484 | 0.8983 | |
| HCC1428 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 11936.135 | 0.9282 | 0.8338 | 0.8584 | |
| HCC1428 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 11936.135 | 0.8999 | 0.7687 | 0.8584 | |
| HCC1428 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 11936.135 | 0.9832 | 0.9609 | 0.8584 | |
| HCC1428 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 11936.135 | 0.9580 | 0.9025 | 0.8584 | |
| HCC1428 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 11936.135 | 0.7578 | 0.4479 | 0.8584 | |
| HCC1428 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 11936.135 | 0.5579 | 0.0133 | 0.8584 | |
| HCC1428 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 11936.135 | 0.6373 | 0.1833 | 0.8584 | |
| HCC1428 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 11936.135 | 0.6273 | 0.1617 | 0.8584 |