Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 11851.135 | 0.9306 | 0.8900 | 1.2721 | |
| SK-BR-3 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 11851.135 | 1.0108 | 1.0169 | 1.2721 | |
| SK-BR-3 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 11851.135 | 0.9347 | 0.8965 | 1.2721 | |
| SK-BR-3 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 11851.135 | 0.8899 | 0.8248 | 1.2721 | |
| SK-BR-3 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 11851.135 | 0.7477 | 0.5914 | 1.2721 | |
| SK-BR-3 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 11851.135 | 0.5542 | 0.2575 | 1.2721 | |
| SK-BR-3 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 11851.135 | 0.4717 | 0.1079 | 1.2721 | |
| SK-BR-3 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 11851.135 | 0.4355 | 0.0405 | 1.2721 | |
| SK-BR-3 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 11851.135 | 0.5138 | 0.1850 | 1.2721 | |
| SUM1315MO2 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 10875.148 | 0.9224 | 0.7984 | 0.7605 | |
| SUM1315MO2 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 10875.148 | 1.0223 | 1.0588 | 0.7605 | |
| SUM1315MO2 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 10875.148 | 0.8139 | 0.5256 | 0.7605 | |
| SUM1315MO2 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 10875.148 | 0.8283 | 0.5612 | 0.7605 | |
| SUM1315MO2 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 10875.148 | 0.6693 | 0.1796 | 0.7605 | |
| SUM1315MO2 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 10875.148 | 0.8803 | 0.6913 | 0.7605 | |
| SUM1315MO2 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 10875.148 | 1.0386 | 1.1021 | 0.7605 | |
| SUM1315MO2 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 10875.148 | 0.9788 | 0.9445 | 0.7605 | |
| SUM1315MO2 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 10875.148 | 1.0299 | 1.0790 | 0.7605 | |
| SUM1315MO2 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 12428.135 | 1.0141 | 1.0319 | 0.8862 | |
| SUM1315MO2 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 12428.135 | 0.9851 | 0.9664 | 0.8862 | |
| SUM1315MO2 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 12428.135 | 1.0041 | 1.0092 | 0.8862 | |
| SUM1315MO2 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 12428.135 | 0.8914 | 0.7567 | 0.8862 | |
| SUM1315MO2 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 12428.135 | 0.6694 | 0.2715 | 0.8862 | |
| SUM1315MO2 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 12428.135 | 0.5529 | 0.0247 | 0.8862 | |
| SUM1315MO2 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 12428.135 | 0.4275 | -0.2334 | 0.8862 |