Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 10578.135 | 0.8467 | 0.8201 | 1.7650 | |
| HCC38 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 10578.135 | 0.8959 | 0.8792 | 1.7650 | |
| HCC38 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 10578.135 | 0.6082 | 0.5090 | 1.7650 | |
| HCC38 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 10578.135 | 0.1957 | -0.2064 | 1.7650 | |
| HCC38 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 10578.135 | 0.1093 | -0.4293 | 1.7650 | |
| HCC38 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 10578.135 | 0.0946 | -0.4743 | 1.7650 | |
| HCC38 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 10578.135 | 0.0801 | -0.5216 | 1.7650 | |
| HCC38 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 11850.135 | 0.9089 | 0.9022 | 1.9060 | |
| HCC38 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 11850.135 | 0.8988 | 0.8912 | 1.9060 | |
| HCC38 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 11850.135 | 0.9110 | 0.9045 | 1.9060 | |
| HCC38 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 11850.135 | 0.6981 | 0.6563 | 1.9060 | |
| HCC38 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 11850.135 | 0.1793 | -0.1883 | 1.9060 | |
| HCC38 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 11850.135 | 0.0467 | -0.5991 | 1.9060 | |
| HCC38 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 11850.135 | 0.0371 | -0.6446 | 1.9060 | |
| HCC38 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 11850.135 | 0.0459 | -0.6029 | 1.9060 | |
| HCC38 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 11850.135 | 0.0292 | -0.6865 | 1.9060 | |
| HCC70 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 10873.148 | 0.9699 | 0.9502 | 1.2150 | |
| HCC70 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 10873.148 | 0.9307 | 0.8853 | 1.2150 | |
| HCC70 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 10873.148 | 0.6795 | 0.4552 | 1.2150 | |
| HCC70 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 10873.148 | 0.9478 | 0.9136 | 1.2150 | |
| HCC70 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 10873.148 | 0.7578 | 0.5918 | 1.2150 | |
| HCC70 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 10873.148 | 0.9342 | 0.8910 | 1.2150 | |
| HCC70 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 10873.148 | 0.9828 | 0.9716 | 1.2150 | |
| HCC70 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 10873.148 | 0.9493 | 0.9161 | 1.2150 | |
| HCC70 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 10873.148 | 1.0612 | 1.1002 | 1.2150 |