Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC2185 | TNBC | Luminal | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 12192.135 | 0.9930 | 0.9775 | 0.6212 | |
| HCC2185 | TNBC | Luminal | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 12192.135 | 0.7634 | 0.2950 | 0.6212 | |
| HCC2185 | TNBC | Luminal | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 12192.135 | 0.7645 | 0.2982 | 0.6212 | |
| HCC2185 | TNBC | Luminal | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 12192.135 | 0.7049 | 0.1391 | 0.6212 | |
| HCC2185 | TNBC | Luminal | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 12192.135 | 0.7097 | 0.1516 | 0.6212 | |
| HCC3153 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 10577.135 | 0.9383 | 0.8849 | 1.0749 | |
| HCC3153 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 10577.135 | 0.9696 | 0.9433 | 1.0749 | |
| HCC3153 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 10577.135 | 0.8606 | 0.7393 | 1.0749 | |
| HCC3153 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 10577.135 | 0.9637 | 0.9324 | 1.0749 | |
| HCC3153 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 10577.135 | 0.9333 | 0.8756 | 1.0749 | |
| HCC3153 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 10577.135 | 0.7247 | 0.4823 | 1.0749 | |
| HCC3153 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 10577.135 | 0.4498 | -0.0489 | 1.0749 | |
| HCC3153 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 10577.135 | 0.2717 | -0.4049 | 1.0749 | |
| HCC3153 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 10577.135 | 0.1857 | -0.5825 | 1.0749 | |
| HCC3153 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 10937.148 | 0.9622 | 0.9479 | 1.4600 | |
| HCC3153 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 10937.148 | 1.0622 | 1.0844 | 1.4600 | |
| HCC3153 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 10937.148 | 0.9731 | 0.9630 | 1.4600 | |
| HCC3153 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 10937.148 | 0.9611 | 0.9464 | 1.4600 | |
| HCC3153 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 10937.148 | 0.8548 | 0.7962 | 1.4600 | |
| HCC3153 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 10937.148 | 0.4129 | 0.0912 | 1.4600 | |
| HCC3153 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 10937.148 | 0.2778 | -0.1682 | 1.4600 | |
| HCC3153 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 10937.148 | 0.2155 | -0.3010 | 1.4600 | |
| HCC3153 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 10937.148 | 0.1613 | -0.4268 | 1.4600 | |
| HCC38 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 10578.135 | 0.9413 | 0.9326 | 1.7650 | |
| HCC38 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 10578.135 | 0.9788 | 0.9759 | 1.7650 |