Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM1315MO2 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 12428.135 | 0.3957 | -0.2974 | 0.8862 | |
| SUM1315MO2 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 12428.135 | 0.3570 | -0.3745 | 0.8862 | |
| SUM149PT | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 10819.148 | 0.9614 | 0.9628 | 2.0950 | |
| SUM149PT | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 10819.148 | 0.9676 | 0.9688 | 2.0950 | |
| SUM149PT | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 10819.148 | 0.9713 | 0.9724 | 2.0950 | |
| SUM149PT | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 10819.148 | 0.8646 | 0.8658 | 2.0950 | |
| SUM149PT | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 10819.148 | 0.7016 | 0.6888 | 2.0950 | |
| SUM149PT | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 10819.148 | 0.3199 | 0.1608 | 2.0950 | |
| SUM149PT | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 10819.148 | 0.1545 | -0.1800 | 2.0950 | |
| SUM149PT | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 10819.148 | 0.0735 | -0.4246 | 2.0950 | |
| SUM149PT | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 10819.148 | 0.0413 | -0.5630 | 2.0950 | |
| SUM149PT | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 11937.135 | 0.9556 | 0.9632 | 2.4451 | |
| SUM149PT | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 11937.135 | 0.9563 | 0.9638 | 2.4451 | |
| SUM149PT | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 11937.135 | 0.9560 | 0.9635 | 2.4451 | |
| SUM149PT | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 11937.135 | 0.9565 | 0.9640 | 2.4451 | |
| SUM149PT | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 11937.135 | 0.7246 | 0.7531 | 2.4451 | |
| SUM149PT | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 11937.135 | 0.3655 | 0.3251 | 2.4451 | |
| SUM149PT | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 11937.135 | 0.0939 | -0.2400 | 2.4451 | |
| SUM149PT | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 11937.135 | 0.0522 | -0.4024 | 2.4451 | |
| SUM149PT | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 11937.135 | 0.0272 | -0.5423 | 2.4451 | |
| SUM159PT | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 10520.135 | 1.0163 | 1.0088 | 3.6895 | |
| SUM159PT | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 10520.135 | 1.0275 | 1.0148 | 3.6895 | |
| SUM159PT | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 10520.135 | 1.0511 | 1.0272 | 3.6895 | |
| SUM159PT | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 10520.135 | 1.1171 | 1.0609 | 3.6895 | |
| SUM159PT | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 10520.135 | 0.8857 | 0.9353 | 3.6895 |