Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 12239.135 | 0.1300 | -0.2479 | 2.0860 | |
| HCC1806 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 12239.135 | 0.1078 | -0.3126 | 2.0860 | |
| HCC1806 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 12239.135 | 0.0583 | -0.4881 | 2.0860 | |
| HCC1937 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 11849.135 | 0.8653 | 0.8080 | 1.4337 | |
| HCC1937 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 11849.135 | 0.9614 | 0.9458 | 1.4337 | |
| HCC1937 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 11849.135 | 0.9483 | 0.9274 | 1.4337 | |
| HCC1937 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 11849.135 | 0.9351 | 0.9086 | 1.4337 | |
| HCC1937 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 11849.135 | 0.9262 | 0.8959 | 1.4337 | |
| HCC1937 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 11849.135 | 0.7530 | 0.6410 | 1.4337 | |
| HCC1937 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 11849.135 | 0.6913 | 0.5460 | 1.4337 | |
| HCC1937 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 11849.135 | 0.6231 | 0.4379 | 1.4337 | |
| HCC1937 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 11849.135 | 0.5612 | 0.3368 | 1.4337 | |
| HCC1954 | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 11055.135 | 0.9272 | 0.9136 | 1.7110 | |
| HCC1954 | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 11055.135 | 0.9513 | 0.9424 | 1.7110 | |
| HCC1954 | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 11055.135 | 1.0131 | 1.0152 | 1.7110 | |
| HCC1954 | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 11055.135 | 0.9814 | 0.9782 | 1.7110 | |
| HCC1954 | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 11055.135 | 1.0068 | 1.0080 | 1.7110 | |
| HCC1954 | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 11055.135 | 0.9092 | 0.8918 | 1.7110 | |
| HCC1954 | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 11055.135 | 0.7709 | 0.7178 | 1.7110 | |
| HCC1954 | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 11055.135 | 0.3909 | 0.1551 | 1.7110 | |
| HCC1954 | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 11055.135 | 0.3139 | 0.0162 | 1.7110 | |
| HCC2185 | TNBC | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 12192.135 | 1.0427 | 1.1392 | 0.6212 | |
| HCC2185 | TNBC | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 12192.135 | 1.0642 | 1.2106 | 0.6212 | |
| HCC2185 | TNBC | Luminal | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 12192.135 | 0.9609 | 0.8757 | 0.6212 | |
| HCC2185 | TNBC | Luminal | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 12192.135 | 1.1049 | 1.3485 | 0.6212 |