Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7475.084 | 1.1147 | 1.0797 | 2.7804 | |
| Hs 578T | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 333 | uM | 7475.084 | 1.1243 | 1.0860 | 2.7804 | |
| LY2 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7477.084 | 0.8758 | 0.7387 | 0.9476 | |
| LY2 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7477.084 | 0.9845 | 0.9674 | 0.9476 | |
| LY2 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7477.084 | 0.9222 | 0.8361 | 0.9476 | |
| LY2 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7477.084 | 0.6741 | 0.3192 | 0.9476 | |
| LY2 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7477.084 | 0.6290 | 0.2261 | 0.9476 | |
| LY2 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7477.084 | 0.7764 | 0.5313 | 0.9476 | |
| LY2 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7477.084 | 0.8431 | 0.6703 | 0.9476 | |
| LY2 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7477.084 | 0.8461 | 0.6766 | 0.9476 | |
| LY2 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 333 | uM | 7477.084 | 0.7274 | 0.4295 | 0.9476 | |
| MB 157 | Unknown | Unknown | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7482.084 | 1.0369 | 1.0391 | 1.8697 | |
| MB 157 | Unknown | Unknown | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7482.084 | 0.9384 | 0.9332 | 1.8697 | |
| MB 157 | Unknown | Unknown | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7482.084 | 0.2909 | 0.0333 | 1.8697 | |
| MB 157 | Unknown | Unknown | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7482.084 | 0.3260 | 0.0982 | 1.8697 | |
| MB 157 | Unknown | Unknown | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7482.084 | 0.4723 | 0.3391 | 1.8697 | |
| MB 157 | Unknown | Unknown | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7482.084 | 0.3790 | 0.1904 | 1.8697 | |
| MB 157 | Unknown | Unknown | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7482.084 | 0.3279 | 0.1016 | 1.8697 | |
| MB 157 | Unknown | Unknown | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7482.084 | 0.3691 | 0.1737 | 1.8697 | |
| MB 157 | Unknown | Unknown | Methotrexate | DHFR | Metabolism | 333 | uM | 7482.084 | 0.3552 | 0.1498 | 1.8697 | |
| MCF 10A | NM | Basal B | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7483.084 | 0.9763 | 0.9854 | 3.2830 | |
| MCF 10A | NM | Basal B | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7483.084 | 0.9444 | 0.9655 | 3.2830 | |
| MCF 10A | NM | Basal B | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7483.084 | 0.7733 | 0.8493 | 3.2830 | |
| MCF 10A | NM | Basal B | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7483.084 | 0.9940 | 0.9964 | 3.2830 | |
| MCF 10A | NM | Basal B | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7483.084 | 0.9975 | 0.9985 | 3.2830 |