Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | NM | Basal B | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7483.084 | 1.0161 | 1.0097 | 3.2830 | |
| MCF 10A | NM | Basal B | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7483.084 | 1.0099 | 1.0060 | 3.2830 | |
| MCF 10A | NM | Basal B | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7483.084 | 0.9303 | 0.9565 | 3.2830 | |
| MCF 10A | NM | Basal B | Methotrexate | DHFR | Metabolism | 333 | uM | 7483.084 | 0.9226 | 0.9515 | 3.2830 | |
| MCF 10A | NM | Basal B | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7484.084 | 0.9806 | 0.9851 | 2.6217 | |
| MCF 10A | NM | Basal B | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7484.084 | 1.0492 | 1.0370 | 2.6217 | |
| MCF 10A | NM | Basal B | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7484.084 | 0.9972 | 0.9979 | 2.6217 | |
| MCF 10A | NM | Basal B | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7484.084 | 0.3101 | 0.2796 | 2.6217 | |
| MCF 10A | NM | Basal B | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7484.084 | 0.2512 | 0.1808 | 2.6217 | |
| MCF 10A | NM | Basal B | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7484.084 | 0.4036 | 0.4149 | 2.6217 | |
| MCF 10A | NM | Basal B | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7484.084 | 0.3144 | 0.2863 | 2.6217 | |
| MCF 10A | NM | Basal B | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7484.084 | 0.4457 | 0.4695 | 2.6217 | |
| MCF 10A | NM | Basal B | Methotrexate | DHFR | Metabolism | 333 | uM | 7484.084 | 0.4009 | 0.4113 | 2.6217 | |
| MCF 10A | NM | Basal B | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7485.085 | 1.0258 | 1.0140 | 3.6369 | |
| MCF 10A | NM | Basal B | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7485.085 | 0.9249 | 0.9575 | 3.6369 | |
| MCF 10A | NM | Basal B | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7485.085 | 0.2662 | 0.3899 | 3.6369 | |
| MCF 10A | NM | Basal B | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7485.085 | 0.3592 | 0.5093 | 3.6369 | |
| MCF 10A | NM | Basal B | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7485.085 | 0.3486 | 0.4969 | 3.6369 | |
| MCF 10A | NM | Basal B | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7485.085 | 0.3895 | 0.5433 | 3.6369 | |
| MCF 10A | NM | Basal B | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7485.085 | 0.3548 | 0.5041 | 3.6369 | |
| MCF 10A | NM | Basal B | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7485.085 | 0.3787 | 0.5314 | 3.6369 | |
| MCF 10A | NM | Basal B | Methotrexate | DHFR | Metabolism | 333 | uM | 7485.085 | 0.4853 | 0.6395 | 3.6369 | |
| MCF 10F | NM | - | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7487.084 | 1.0091 | 1.0136 | 1.3396 | |
| MCF 10F | NM | - | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7487.084 | 1.0063 | 1.0093 | 1.3396 | |
| MCF 10F | NM | - | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7487.084 | 1.0094 | 1.0140 | 1.3396 |