Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset - HMS LINCS Database

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)

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Small molecules	Cells	Antibodies

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Cell	Clinical Subtype	Transcriptional Subtype	Small Molecule	Perturbagen Target	Perturbagen Class	Perturbagen Concentration	Perturbagen Conc Unit	Biological Replicate ID	Relative Cell Count	Normalized Growth Rate Inhibition Value	Nominal Division Rate
MCF 10F	NM	-	Methotrexate	DHFR	Metabolism	0.107	uM	7487.084	0.6311	0.4184	1.3396
MCF 10F	NM	-	Methotrexate	DHFR	Metabolism	0.533	uM	7487.084	0.5546	0.2879	1.3396
MCF 10F	NM	-	Methotrexate	DHFR	Metabolism	2.67	uM	7487.084	0.5770	0.3266	1.3396
MCF 10F	NM	-	Methotrexate	DHFR	Metabolism	13.3	uM	7487.084	0.5781	0.3285	1.3396
MCF 10F	NM	-	Methotrexate	DHFR	Metabolism	66.7	uM	7487.084	0.5581	0.2941	1.3396
MCF 10F	NM	-	Methotrexate	DHFR	Metabolism	333	uM	7487.084	0.5471	0.2750	1.3396
MCF12A	NM	Basal B	Methotrexate	DHFR	Metabolism	0.000853	uM	7489.084	0.9928	0.9929	2.0279
MCF12A	NM	Basal B	Methotrexate	DHFR	Metabolism	0.00427	uM	7489.084	0.9509	0.9510	2.0279
MCF12A	NM	Basal B	Methotrexate	DHFR	Metabolism	0.0213	uM	7489.084	1.0265	1.0260	2.0279
MCF12A	NM	Basal B	Methotrexate	DHFR	Metabolism	0.107	uM	7489.084	0.7762	0.7651	2.0279
MCF12A	NM	Basal B	Methotrexate	DHFR	Metabolism	0.533	uM	7489.084	0.7884	0.7787	2.0279
MCF12A	NM	Basal B	Methotrexate	DHFR	Metabolism	2.67	uM	7489.084	0.8270	0.8211	2.0279
MCF12A	NM	Basal B	Methotrexate	DHFR	Metabolism	13.3	uM	7489.084	0.8078	0.8002	2.0279
MCF12A	NM	Basal B	Methotrexate	DHFR	Metabolism	66.7	uM	7489.084	0.7119	0.6914	2.0279
MCF12A	NM	Basal B	Methotrexate	DHFR	Metabolism	333	uM	7489.084	0.7474	0.7325	2.0279
MCF12A	NM	Basal B	Methotrexate	DHFR	Metabolism	0.000853	uM	7490.085	0.9857	0.9889	2.5778
MCF12A	NM	Basal B	Methotrexate	DHFR	Metabolism	0.00427	uM	7490.085	0.9175	0.9343	2.5778
MCF12A	NM	Basal B	Methotrexate	DHFR	Metabolism	0.0213	uM	7490.085	0.9647	0.9723	2.5778
MCF12A	NM	Basal B	Methotrexate	DHFR	Metabolism	0.107	uM	7490.085	0.5859	0.6254	2.5778
MCF12A	NM	Basal B	Methotrexate	DHFR	Metabolism	0.533	uM	7490.085	0.4709	0.4933	2.5778
MCF12A	NM	Basal B	Methotrexate	DHFR	Metabolism	2.67	uM	7490.085	0.3801	0.3742	2.5778
MCF12A	NM	Basal B	Methotrexate	DHFR	Metabolism	13.3	uM	7490.085	0.3756	0.3678	2.5778
MCF12A	NM	Basal B	Methotrexate	DHFR	Metabolism	66.7	uM	7490.085	0.3687	0.3581	2.5778
MCF12A	NM	Basal B	Methotrexate	DHFR	Metabolism	333	uM	7490.085	0.3977	0.3986	2.5778
MCF7	HR+	Luminal	Methotrexate	DHFR	Metabolism	0.000853	uM	7492.084	1.0875	1.1162	1.4850

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HMS LINCS Project

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)