Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7443.084 | 0.8942 | 0.7860 | 0.9878 | |
| HCC1428 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7443.084 | 0.9511 | 0.9010 | 0.9878 | |
| HCC1428 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7443.084 | 0.9064 | 0.8105 | 0.9878 | |
| HCC1428 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 333 | uM | 7443.084 | 0.9252 | 0.8487 | 0.9878 | |
| HCC1428 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7444.084 | 0.9360 | 0.8527 | 0.8647 | |
| HCC1428 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7444.084 | 1.0207 | 1.0480 | 0.8647 | |
| HCC1428 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7444.084 | 0.9799 | 0.9536 | 0.8647 | |
| HCC1428 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7444.084 | 0.9437 | 0.8705 | 0.8647 | |
| HCC1428 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7444.084 | 0.8281 | 0.6080 | 0.8647 | |
| HCC1428 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7444.084 | 0.8710 | 0.7047 | 0.8647 | |
| HCC1428 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7444.084 | 0.8221 | 0.5945 | 0.8647 | |
| HCC1428 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7444.084 | 0.7980 | 0.5406 | 0.8647 | |
| HCC1428 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 333 | uM | 7444.084 | 0.8206 | 0.5913 | 0.8647 | |
| HCC1569 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7447.084 | 1.0374 | 1.0490 | 1.5152 | |
| HCC1569 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7447.084 | 1.0172 | 1.0226 | 1.5152 | |
| HCC1569 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7447.084 | 0.9747 | 0.9665 | 1.5152 | |
| HCC1569 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7447.084 | 1.0553 | 1.0723 | 1.5152 | |
| HCC1569 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7447.084 | 1.0013 | 1.0018 | 1.5152 | |
| HCC1569 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7447.084 | 1.0013 | 1.0018 | 1.5152 | |
| HCC1569 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7447.084 | 0.9998 | 0.9998 | 1.5152 | |
| HCC1569 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7447.084 | 0.9747 | 0.9665 | 1.5152 | |
| HCC1569 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 333 | uM | 7447.084 | 0.9838 | 0.9785 | 1.5152 | |
| HCC1569 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7448.084 | 0.9968 | 0.9977 | 2.8225 | |
| HCC1569 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7448.084 | 0.9870 | 0.9908 | 2.8225 | |
| HCC1569 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7448.084 | 1.0424 | 1.0297 | 2.8225 |