Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1569 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7448.084 | 0.9567 | 0.9689 | 2.8225 | |
| HCC1569 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7448.084 | 0.9660 | 0.9757 | 2.8225 | |
| HCC1569 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7448.084 | 0.9588 | 0.9704 | 2.8225 | |
| HCC1569 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7448.084 | 0.9353 | 0.9532 | 2.8225 | |
| HCC1569 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7448.084 | 0.9248 | 0.9454 | 2.8225 | |
| HCC1569 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 333 | uM | 7448.084 | 0.9579 | 0.9697 | 2.8225 | |
| HCC1569 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7449.084 | 0.9741 | 0.9756 | 2.1410 | |
| HCC1569 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7449.084 | 0.9406 | 0.9436 | 2.1410 | |
| HCC1569 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7449.084 | 0.9518 | 0.9543 | 2.1410 | |
| HCC1569 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7449.084 | 0.9689 | 0.9707 | 2.1410 | |
| HCC1569 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7449.084 | 0.9292 | 0.9326 | 2.1410 | |
| HCC1569 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7449.084 | 0.9814 | 0.9826 | 2.1410 | |
| HCC1569 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7449.084 | 0.9785 | 0.9798 | 2.1410 | |
| HCC1569 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7449.084 | 0.9294 | 0.9327 | 2.1410 | |
| HCC1569 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 333 | uM | 7449.084 | 0.9462 | 0.9490 | 2.1410 | |
| HCC1806 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7450.084 | 1.0262 | 1.0222 | 2.3432 | |
| HCC1806 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7450.084 | 1.0109 | 1.0092 | 2.3432 | |
| HCC1806 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7450.084 | 1.0186 | 1.0158 | 2.3432 | |
| HCC1806 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7450.084 | 1.0428 | 1.0361 | 2.3432 | |
| HCC1806 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7450.084 | 0.9574 | 0.9632 | 2.3432 | |
| HCC1806 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7450.084 | 1.0277 | 1.0234 | 2.3432 | |
| HCC1806 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7450.084 | 1.0233 | 1.0198 | 2.3432 | |
| HCC1806 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7450.084 | 0.9422 | 0.9498 | 2.3432 | |
| HCC1806 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 333 | uM | 7450.084 | 0.9339 | 0.9424 | 2.3432 | |
| HCC1806 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7451.085 | 0.9451 | 0.9480 | 2.1458 |