Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7492.084 | 0.9195 | 0.8901 | 1.4850 | |
| MCF7 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7492.084 | 0.8738 | 0.8263 | 1.4850 | |
| MCF7 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7492.084 | 0.6536 | 0.5020 | 1.4850 | |
| MCF7 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7492.084 | 0.6385 | 0.4785 | 1.4850 | |
| MCF7 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7492.084 | 0.6198 | 0.4491 | 1.4850 | |
| MCF7 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7492.084 | 0.6562 | 0.5060 | 1.4850 | |
| MCF7 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7492.084 | 0.6191 | 0.4481 | 1.4850 | |
| MCF7 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 333 | uM | 7492.084 | 0.6269 | 0.4603 | 1.4850 | |
| MCF7 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7493.085 | 0.8416 | 0.7713 | 1.4204 | |
| MCF7 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7493.085 | 0.9761 | 0.9663 | 1.4204 | |
| MCF7 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7493.085 | 0.7408 | 0.6192 | 1.4204 | |
| MCF7 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7493.085 | 0.4691 | 0.1738 | 1.4204 | |
| MCF7 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7493.085 | 0.4844 | 0.2007 | 1.4204 | |
| MCF7 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7493.085 | 0.4901 | 0.2105 | 1.4204 | |
| MCF7 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7493.085 | 0.4891 | 0.2088 | 1.4204 | |
| MCF7 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7493.085 | 0.4552 | 0.1493 | 1.4204 | |
| MCF7 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 333 | uM | 7493.085 | 0.4818 | 0.1960 | 1.4204 | |
| MDA-MB-134-VI | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7494.084 | 0.9478 | 0.8984 | 1.0275 | |
| MDA-MB-134-VI | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7494.084 | 0.8447 | 0.6971 | 1.0275 | |
| MDA-MB-134-VI | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7494.084 | 0.9839 | 0.9687 | 1.0275 | |
| MDA-MB-134-VI | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7494.084 | 0.9556 | 0.9135 | 1.0275 | |
| MDA-MB-134-VI | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7494.084 | 0.9260 | 0.8558 | 1.0275 | |
| MDA-MB-134-VI | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7494.084 | 0.9735 | 0.9484 | 1.0275 | |
| MDA-MB-134-VI | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7494.084 | 0.9556 | 0.9135 | 1.0275 | |
| MDA-MB-134-VI | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7494.084 | 0.9490 | 0.9007 | 1.0275 |