Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-134-VI | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 333 | uM | 7494.084 | 0.9315 | 0.8665 | 1.0275 | |
| MDA-MB-157 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7496.085 | 1.0129 | 1.0240 | 1.0748 | |
| MDA-MB-157 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7496.085 | 0.9446 | 0.8967 | 1.0748 | |
| MDA-MB-157 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7496.085 | 0.8261 | 0.6743 | 1.0748 | |
| MDA-MB-157 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7496.085 | 0.4883 | 0.0265 | 1.0748 | |
| MDA-MB-157 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7496.085 | 0.4836 | 0.0173 | 1.0748 | |
| MDA-MB-157 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7496.085 | 0.5228 | 0.0940 | 1.0748 | |
| MDA-MB-157 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7496.085 | 0.4882 | 0.0263 | 1.0748 | |
| MDA-MB-157 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7496.085 | 0.5030 | 0.0553 | 1.0748 | |
| MDA-MB-157 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 333 | uM | 7496.085 | 0.4953 | 0.0403 | 1.0748 | |
| MDA-MB-157 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7498.084 | 0.9357 | 0.8900 | 1.1749 | |
| MDA-MB-157 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7498.084 | 0.9758 | 0.9587 | 1.1749 | |
| MDA-MB-157 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7498.084 | 0.8818 | 0.7969 | 1.1749 | |
| MDA-MB-157 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7498.084 | 0.7296 | 0.5293 | 1.1749 | |
| MDA-MB-157 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7498.084 | 0.7359 | 0.5406 | 1.1749 | |
| MDA-MB-157 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7498.084 | 0.7347 | 0.5383 | 1.1749 | |
| MDA-MB-157 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7498.084 | 0.6939 | 0.4654 | 1.1749 | |
| MDA-MB-157 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7498.084 | 0.7413 | 0.5502 | 1.1749 | |
| MDA-MB-157 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 333 | uM | 7498.084 | 0.7336 | 0.5364 | 1.1749 | |
| MDA-MB-175-VII | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7499.084 | 0.9044 | 0.7636 | 0.7991 | |
| MDA-MB-175-VII | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7499.084 | 0.9159 | 0.7918 | 0.7991 | |
| MDA-MB-175-VII | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7499.084 | 0.9526 | 0.8820 | 0.7991 | |
| MDA-MB-175-VII | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7499.084 | 0.9744 | 0.9361 | 0.7991 | |
| MDA-MB-175-VII | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7499.084 | 0.9888 | 0.9721 | 0.7991 | |
| MDA-MB-175-VII | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7499.084 | 1.0082 | 1.0205 | 0.7991 |