Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7473.084 | 1.0415 | 1.0404 | 2.0337 | |
| Hs 578T | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7473.084 | 1.1102 | 1.1055 | 2.0337 | |
| Hs 578T | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7473.084 | 1.0075 | 1.0073 | 2.0337 | |
| Hs 578T | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7473.084 | 1.0095 | 1.0094 | 2.0337 | |
| Hs 578T | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7473.084 | 1.0392 | 1.0382 | 2.0337 | |
| Hs 578T | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7473.084 | 0.8124 | 0.8058 | 2.0337 | |
| Hs 578T | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7473.084 | 0.8635 | 0.8608 | 2.0337 | |
| Hs 578T | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7473.084 | 0.8405 | 0.8363 | 2.0337 | |
| Hs 578T | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 333 | uM | 7473.084 | 0.9363 | 0.9363 | 2.0337 | |
| Hs 578T | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7474.084 | 1.0880 | 1.0643 | 2.6631 | |
| Hs 578T | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7474.084 | 1.0472 | 1.0349 | 2.6631 | |
| Hs 578T | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7474.084 | 0.7480 | 0.7935 | 2.6631 | |
| Hs 578T | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7474.084 | 0.9302 | 0.9464 | 2.6631 | |
| Hs 578T | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7474.084 | 0.8296 | 0.8645 | 2.6631 | |
| Hs 578T | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7474.084 | 0.8116 | 0.8492 | 2.6631 | |
| Hs 578T | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7474.084 | 0.7980 | 0.8375 | 2.6631 | |
| Hs 578T | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7474.084 | 0.8139 | 0.8512 | 2.6631 | |
| Hs 578T | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 333 | uM | 7474.084 | 1.0461 | 1.0341 | 2.6631 | |
| Hs 578T | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7475.084 | 1.2395 | 1.1606 | 2.7804 | |
| Hs 578T | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7475.084 | 1.1020 | 1.0711 | 2.7804 | |
| Hs 578T | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7475.084 | 1.0594 | 1.0419 | 2.7804 | |
| Hs 578T | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7475.084 | 0.9988 | 0.9992 | 2.7804 | |
| Hs 578T | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7475.084 | 1.2610 | 1.1739 | 2.7804 | |
| Hs 578T | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7475.084 | 1.0756 | 1.0531 | 2.7804 | |
| Hs 578T | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7475.084 | 1.0576 | 1.0407 | 2.7804 |