Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1143 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7430.085 | 0.7501 | 0.7269 | 1.9592 | |
| HCC1143 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7430.085 | 0.5233 | 0.4370 | 1.9592 | |
| HCC1143 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7430.085 | 0.5260 | 0.4408 | 1.9592 | |
| HCC1143 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7430.085 | 0.5648 | 0.4941 | 1.9592 | |
| HCC1143 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7430.085 | 0.5060 | 0.4125 | 1.9592 | |
| HCC1143 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7430.085 | 0.5218 | 0.4350 | 1.9592 | |
| HCC1143 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 333 | uM | 7430.085 | 0.5228 | 0.4364 | 1.9592 | |
| HCC1187 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7432.084 | 1.1248 | 1.2953 | 0.8538 | |
| HCC1187 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7432.084 | 1.0729 | 1.1718 | 0.8538 | |
| HCC1187 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7432.084 | 1.0179 | 1.0420 | 0.8538 | |
| HCC1187 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7432.084 | 0.9147 | 0.8017 | 0.8538 | |
| HCC1187 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7432.084 | 0.9306 | 0.8383 | 0.8538 | |
| HCC1187 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7432.084 | 0.9987 | 0.9970 | 0.8538 | |
| HCC1187 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7432.084 | 0.9351 | 0.8488 | 0.8538 | |
| HCC1187 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7432.084 | 0.9064 | 0.7826 | 0.8538 | |
| HCC1187 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 333 | uM | 7432.084 | 0.9461 | 0.8743 | 0.8538 | |
| HCC1187 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7433.084 | 0.9948 | 0.9898 | 1.0291 | |
| HCC1187 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7433.084 | 1.0395 | 1.0768 | 1.0291 | |
| HCC1187 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7433.084 | 0.6721 | 0.3593 | 1.0291 | |
| HCC1187 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7433.084 | 0.5715 | 0.1612 | 1.0291 | |
| HCC1187 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7433.084 | 0.5553 | 0.1291 | 1.0291 | |
| HCC1187 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7433.084 | 0.5743 | 0.1667 | 1.0291 | |
| HCC1187 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7433.084 | 0.6049 | 0.2272 | 1.0291 | |
| HCC1187 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7433.084 | 0.5802 | 0.1784 | 1.0291 | |
| HCC1187 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 333 | uM | 7433.084 | 0.5479 | 0.1147 | 1.0291 |