Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7435.084 | 1.0185 | 1.0429 | 0.8646 | |
| HCC1395 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7435.084 | 0.9749 | 0.9420 | 0.8646 | |
| HCC1395 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7435.084 | 0.9388 | 0.8592 | 0.8646 | |
| HCC1395 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7435.084 | 0.9552 | 0.8967 | 0.8646 | |
| HCC1395 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7435.084 | 0.9891 | 0.9748 | 0.8646 | |
| HCC1395 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7435.084 | 0.9769 | 0.9465 | 0.8646 | |
| HCC1395 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7435.084 | 0.9747 | 0.9416 | 0.8646 | |
| HCC1395 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7435.084 | 0.9959 | 0.9904 | 0.8646 | |
| HCC1395 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 333 | uM | 7435.084 | 0.9960 | 0.9908 | 0.8646 | |
| HCC1395 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7436.085 | 1.0780 | 1.1227 | 1.2621 | |
| HCC1395 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7436.085 | 1.0005 | 1.0007 | 1.2621 | |
| HCC1395 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7436.085 | 1.0479 | 1.0755 | 1.2621 | |
| HCC1395 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7436.085 | 1.0212 | 1.0336 | 1.2621 | |
| HCC1395 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7436.085 | 1.0454 | 1.0717 | 1.2621 | |
| HCC1395 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7436.085 | 1.0334 | 1.0527 | 1.2621 | |
| HCC1395 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7436.085 | 1.0378 | 1.0597 | 1.2621 | |
| HCC1395 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7436.085 | 1.0018 | 1.0029 | 1.2621 | |
| HCC1395 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 333 | uM | 7436.085 | 1.0171 | 1.0271 | 1.2621 | |
| HCC1419 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7437.084 | 0.9853 | 0.9328 | 0.4343 | |
| HCC1419 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7437.084 | 0.9548 | 0.7982 | 0.4343 | |
| HCC1419 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7437.084 | 0.9936 | 0.9704 | 0.4343 | |
| HCC1419 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7437.084 | 0.9640 | 0.8382 | 0.4343 | |
| HCC1419 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7437.084 | 0.9138 | 0.6252 | 0.4343 | |
| HCC1419 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7437.084 | 0.9376 | 0.7244 | 0.4343 | |
| HCC1419 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7437.084 | 0.9112 | 0.6145 | 0.4343 |