Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7468.085 | 1.0088 | 1.0123 | 1.4385 | |
| HCC38 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7468.085 | 0.9514 | 0.9319 | 1.4385 | |
| HCC38 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7468.085 | 0.8799 | 0.8298 | 1.4385 | |
| HCC38 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7468.085 | 0.8891 | 0.8430 | 1.4385 | |
| HCC38 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7468.085 | 0.8961 | 0.8532 | 1.4385 | |
| HCC38 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7468.085 | 0.8711 | 0.8170 | 1.4385 | |
| HCC38 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 333 | uM | 7468.085 | 0.8667 | 0.8106 | 1.4385 | |
| HCC38 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7469.084 | 0.8934 | 0.8924 | 2.0377 | |
| HCC38 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7469.084 | 0.9741 | 0.9744 | 2.0377 | |
| HCC38 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7469.084 | 0.9187 | 0.9185 | 2.0377 | |
| HCC38 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7469.084 | 0.9485 | 0.9487 | 2.0377 | |
| HCC38 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7469.084 | 0.8836 | 0.8822 | 2.0377 | |
| HCC38 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7469.084 | 0.9399 | 0.9401 | 2.0377 | |
| HCC38 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7469.084 | 0.9570 | 0.9574 | 2.0377 | |
| HCC38 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7469.084 | 0.9158 | 0.9155 | 2.0377 | |
| HCC38 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 333 | uM | 7469.084 | 0.8902 | 0.8890 | 2.0377 | |
| HCC70 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7470.085 | 0.8303 | 0.6569 | 0.9880 | |
| HCC70 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7470.085 | 0.9274 | 0.8531 | 0.9880 | |
| HCC70 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7470.085 | 0.7122 | 0.4186 | 0.9880 | |
| HCC70 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7470.085 | 0.9936 | 0.9870 | 0.9880 | |
| HCC70 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7470.085 | 0.9206 | 0.8394 | 0.9880 | |
| HCC70 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7470.085 | 0.8148 | 0.6256 | 0.9880 | |
| HCC70 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7470.085 | 0.9613 | 0.9217 | 0.9880 | |
| HCC70 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7470.085 | 0.8466 | 0.6898 | 0.9880 | |
| HCC70 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 333 | uM | 7470.085 | 0.9380 | 0.8746 | 0.9880 |