Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1143 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.267 | uM | 12112.154 | 0.6640 | 0.5995 | 1.8321 | |
| HCC1143 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 1.33 | uM | 12112.154 | 0.4275 | 0.2577 | 1.8321 | |
| HCC1143 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 6.67 | uM | 12112.154 | 0.2152 | -0.1353 | 1.8321 | |
| HCC1143 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 33.3 | uM | 12112.154 | 0.0133 | -0.8107 | 1.8321 | |
| HCC1187 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.000256 | uM | 10518.142 | 1.0167 | 1.0259 | 1.2869 | |
| HCC1187 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.00128 | uM | 10518.142 | 0.9612 | 0.9395 | 1.2869 | |
| HCC1187 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0064 | uM | 10518.142 | 1.0216 | 1.0335 | 1.2869 | |
| HCC1187 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.032 | uM | 10518.142 | 0.9450 | 0.9140 | 1.2869 | |
| HCC1187 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.16 | uM | 10518.142 | 0.8705 | 0.7956 | 1.2869 | |
| HCC1187 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.8 | uM | 10518.142 | 0.5205 | 0.2041 | 1.2869 | |
| HCC1187 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 4 | uM | 10518.142 | 0.5919 | 0.3306 | 1.2869 | |
| HCC1187 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 20 | uM | 10518.142 | 0.0747 | -0.7337 | 1.2869 | |
| HCC1187 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 100 | uM | 10518.142 | 0.0061 | -0.9619 | 1.2869 | |
| HCC1187 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0000853 | uM | 10753.154 | 1.0642 | 1.0880 | 1.4444 | |
| HCC1187 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.000427 | uM | 10753.154 | 1.0300 | 1.0414 | 1.4444 | |
| HCC1187 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.00213 | uM | 10753.154 | 1.0386 | 1.0532 | 1.4444 | |
| HCC1187 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0107 | uM | 10753.154 | 1.0335 | 1.0461 | 1.4444 | |
| HCC1187 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0533 | uM | 10753.154 | 1.0134 | 1.0185 | 1.4444 | |
| HCC1187 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.267 | uM | 10753.154 | 0.8079 | 0.7254 | 1.4444 | |
| HCC1187 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 1.33 | uM | 10753.154 | 0.4311 | 0.1170 | 1.4444 | |
| HCC1187 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 6.67 | uM | 10753.154 | 0.5488 | 0.3201 | 1.4444 | |
| HCC1187 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 33.3 | uM | 10753.154 | 0.0077 | -0.9314 | 1.4444 | |
| HCC1395 | TNBC | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0000853 | uM | 12000.167 | 0.9780 | 0.9391 | 0.7185 | |
| HCC1395 | TNBC | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.000427 | uM | 12000.167 | 0.9232 | 0.7894 | 0.7185 | |
| HCC1395 | TNBC | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.00213 | uM | 12000.167 | 0.9758 | 0.9328 | 0.7185 |