Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM159PT | TNBC | Basal B | LBH589 | HDAC | HDAC | 6.67 | uM | 11057.154 | 0.0004 | -0.7352 | 3.8498 | |
| SUM159PT | TNBC | Basal B | LBH589 | HDAC | HDAC | 33.3 | uM | 11057.154 | 0.0004 | -0.7352 | 3.8498 | |
| SUM185PE | TNBC | Luminal | LBH589 | HDAC | HDAC | 0.0000853 | uM | 12269.154 | 1.0126 | 1.0251 | 0.9999 | |
| SUM185PE | TNBC | Luminal | LBH589 | HDAC | HDAC | 0.000427 | uM | 12269.154 | 1.0059 | 1.0117 | 0.9999 | |
| SUM185PE | TNBC | Luminal | LBH589 | HDAC | HDAC | 0.00213 | uM | 12269.154 | 1.0065 | 1.0131 | 0.9999 | |
| SUM185PE | TNBC | Luminal | LBH589 | HDAC | HDAC | 0.0107 | uM | 12269.154 | 0.9530 | 0.9060 | 0.9999 | |
| SUM185PE | TNBC | Luminal | LBH589 | HDAC | HDAC | 0.0533 | uM | 12269.154 | 0.8382 | 0.6765 | 0.9999 | |
| SUM185PE | TNBC | Luminal | LBH589 | HDAC | HDAC | 0.267 | uM | 12269.154 | 0.4199 | -0.1602 | 0.9999 | |
| SUM185PE | TNBC | Luminal | LBH589 | HDAC | HDAC | 1.33 | uM | 12269.154 | 0.1423 | -0.7155 | 0.9999 | |
| SUM185PE | TNBC | Luminal | LBH589 | HDAC | HDAC | 6.67 | uM | 12269.154 | 0.0619 | -0.8762 | 0.9999 | |
| SUM185PE | TNBC | Luminal | LBH589 | HDAC | HDAC | 33.3 | uM | 12269.154 | 0.0336 | -0.9328 | 0.9999 | |
| SUM225CWN | HER2amp | Basal A | LBH589 | HDAC | HDAC | 0.0000853 | uM | 12098.154 | 1.0442 | 1.0910 | 0.9724 | |
| SUM225CWN | HER2amp | Basal A | LBH589 | HDAC | HDAC | 0.000427 | uM | 12098.154 | 1.0566 | 1.1165 | 0.9724 | |
| SUM225CWN | HER2amp | Basal A | LBH589 | HDAC | HDAC | 0.00213 | uM | 12098.154 | 1.0848 | 1.1746 | 0.9724 | |
| SUM225CWN | HER2amp | Basal A | LBH589 | HDAC | HDAC | 0.0107 | uM | 12098.154 | 1.0433 | 1.0892 | 0.9724 | |
| SUM225CWN | HER2amp | Basal A | LBH589 | HDAC | HDAC | 0.0533 | uM | 12098.154 | 0.8446 | 0.6811 | 0.9724 | |
| SUM225CWN | HER2amp | Basal A | LBH589 | HDAC | HDAC | 0.267 | uM | 12098.154 | 0.5155 | 0.0117 | 0.9724 | |
| SUM225CWN | HER2amp | Basal A | LBH589 | HDAC | HDAC | 1.33 | uM | 12098.154 | 0.0426 | -0.9220 | 0.9724 | |
| SUM225CWN | HER2amp | Basal A | LBH589 | HDAC | HDAC | 6.67 | uM | 12098.154 | 0.0394 | -0.9280 | 0.9724 | |
| SUM225CWN | HER2amp | Basal A | LBH589 | HDAC | HDAC | 33.3 | uM | 12098.154 | 0.0391 | -0.9287 | 0.9724 | |
| SUM229PE | TNBC | - | LBH589 | HDAC | HDAC | 0.0000853 | uM | 11058.154 | 0.9655 | 0.9667 | 2.0897 | |
| SUM229PE | TNBC | - | LBH589 | HDAC | HDAC | 0.000427 | uM | 11058.154 | 1.0002 | 1.0002 | 2.0897 | |
| SUM229PE | TNBC | - | LBH589 | HDAC | HDAC | 0.00213 | uM | 11058.154 | 0.9456 | 0.9472 | 2.0897 | |
| SUM229PE | TNBC | - | LBH589 | HDAC | HDAC | 0.0107 | uM | 11058.154 | 1.1166 | 1.1084 | 2.0897 | |
| SUM229PE | TNBC | - | LBH589 | HDAC | HDAC | 0.0533 | uM | 11058.154 | 1.0386 | 1.0365 | 2.0897 |