Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM229PE | TNBC | - | LBH589 | HDAC | HDAC | 0.267 | uM | 11058.154 | 0.6261 | 0.5985 | 2.0897 | |
| SUM229PE | TNBC | - | LBH589 | HDAC | HDAC | 1.33 | uM | 11058.154 | 0.1334 | -0.2372 | 2.0897 | |
| SUM229PE | TNBC | - | LBH589 | HDAC | HDAC | 6.67 | uM | 11058.154 | 0.0470 | -0.5370 | 2.0897 | |
| SUM229PE | TNBC | - | LBH589 | HDAC | HDAC | 33.3 | uM | 11058.154 | 0.0319 | -0.6155 | 2.0897 | |
| SUM52PE | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.0000853 | uM | 10695.154 | 0.9897 | 0.9860 | 1.4756 | |
| SUM52PE | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.000427 | uM | 10695.154 | 0.9720 | 0.9619 | 1.4756 | |
| SUM52PE | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.00213 | uM | 10695.154 | 0.9556 | 0.9393 | 1.4756 | |
| SUM52PE | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.0107 | uM | 10695.154 | 0.9970 | 0.9959 | 1.4756 | |
| SUM52PE | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.0533 | uM | 10695.154 | 1.0137 | 1.0185 | 1.4756 | |
| SUM52PE | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.267 | uM | 10695.154 | 0.6371 | 0.4734 | 1.4756 | |
| SUM52PE | HR+ | Luminal | LBH589 | HDAC | HDAC | 1.33 | uM | 10695.154 | 0.0286 | -0.8200 | 1.4756 | |
| SUM52PE | HR+ | Luminal | LBH589 | HDAC | HDAC | 6.67 | uM | 10695.154 | 0.0237 | -0.8419 | 1.4756 | |
| SUM52PE | HR+ | Luminal | LBH589 | HDAC | HDAC | 33.3 | uM | 10695.154 | 0.0224 | -0.8474 | 1.4756 | |
| SUM52PE | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.0000853 | uM | 11852.154 | 0.9904 | 0.9850 | 1.2816 | |
| SUM52PE | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.000427 | uM | 11852.154 | 1.0268 | 1.0418 | 1.2816 | |
| SUM52PE | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.00213 | uM | 11852.154 | 1.0218 | 1.0339 | 1.2816 | |
| SUM52PE | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.0107 | uM | 11852.154 | 1.0349 | 1.0542 | 1.2816 | |
| SUM52PE | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.0533 | uM | 11852.154 | 0.8084 | 0.6941 | 1.2816 | |
| SUM52PE | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.267 | uM | 11852.154 | 0.2204 | -0.3855 | 1.2816 | |
| SUM52PE | HR+ | Luminal | LBH589 | HDAC | HDAC | 1.33 | uM | 11852.154 | 0.0276 | -0.8785 | 1.2816 | |
| SUM52PE | HR+ | Luminal | LBH589 | HDAC | HDAC | 6.67 | uM | 11852.154 | 0.0265 | -0.8821 | 1.2816 | |
| SUM52PE | HR+ | Luminal | LBH589 | HDAC | HDAC | 33.3 | uM | 11852.154 | 0.0159 | -0.9211 | 1.2816 | |
| T47D | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.0000853 | uM | 10939.154 | 0.9994 | 0.9993 | 1.6876 | |
| T47D | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.000427 | uM | 10939.154 | 0.9325 | 0.9189 | 1.6876 | |
| T47D | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.00213 | uM | 10939.154 | 1.0286 | 1.0337 | 1.6876 |