Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-812 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 10 | uM | 11938.161 | 0.8517 | 0.6094 | 0.7388 | |
| UACC-812 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 50 | uM | 11938.161 | 0.4860 | -0.2470 | 0.7388 | |
| ZR-75-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0000853 | uM | 11660.149 | 0.9662 | 0.9367 | 1.0690 | |
| ZR-75-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.000427 | uM | 11660.149 | 0.8922 | 0.7975 | 1.0690 | |
| ZR-75-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.00213 | uM | 11660.149 | 0.9168 | 0.8438 | 1.0690 | |
| ZR-75-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0107 | uM | 11660.149 | 0.9647 | 0.9338 | 1.0690 | |
| ZR-75-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0533 | uM | 11660.149 | 0.9682 | 0.9405 | 1.0690 | |
| ZR-75-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.267 | uM | 11660.149 | 0.9093 | 0.8298 | 1.0690 | |
| ZR-75-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 1.33 | uM | 11660.149 | 0.9465 | 0.8997 | 1.0690 | |
| ZR-75-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 6.67 | uM | 11660.149 | 0.9278 | 0.8645 | 1.0690 | |
| ZR-75-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 33.3 | uM | 11660.149 | 0.6682 | 0.3716 | 1.0690 | |
| ZR-75-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0000853 | uM | 12003.166 | 0.9540 | 0.9146 | 1.0782 | |
| ZR-75-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.000427 | uM | 12003.166 | 0.9086 | 0.8299 | 1.0782 | |
| ZR-75-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.00213 | uM | 12003.166 | 0.9689 | 0.9422 | 1.0782 | |
| ZR-75-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0107 | uM | 12003.166 | 0.8618 | 0.7423 | 1.0782 | |
| ZR-75-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0533 | uM | 12003.166 | 0.8670 | 0.7520 | 1.0782 | |
| ZR-75-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.267 | uM | 12003.166 | 0.9039 | 0.8210 | 1.0782 | |
| ZR-75-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 1.33 | uM | 12003.166 | 0.8568 | 0.7328 | 1.0782 | |
| ZR-75-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 6.67 | uM | 12003.166 | 0.9037 | 0.8208 | 1.0782 | |
| ZR-75-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 33.3 | uM | 12003.166 | 0.6538 | 0.3485 | 1.0782 | |
| ZR75B | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.000128 | uM | 11939.161 | 1.0145 | 1.0175 | 1.6513 | |
| ZR75B | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.00064 | uM | 11939.161 | 0.9453 | 0.9330 | 1.6513 | |
| ZR75B | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0032 | uM | 11939.161 | 1.0279 | 1.0336 | 1.6513 | |
| ZR75B | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.016 | uM | 11939.161 | 1.0376 | 1.0452 | 1.6513 | |
| ZR75B | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.08 | uM | 11939.161 | 0.9547 | 0.9447 | 1.6513 |