Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR75B | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.4 | uM | 11939.161 | 1.0148 | 1.0178 | 1.6513 | |
| ZR75B | HR+ | Luminal | L-779450 | BRAF | MAPK | 2 | uM | 11939.161 | 0.8846 | 0.8568 | 1.6513 | |
| ZR75B | HR+ | Luminal | L-779450 | BRAF | MAPK | 10 | uM | 11939.161 | 0.9493 | 0.9380 | 1.6513 | |
| ZR75B | HR+ | Luminal | L-779450 | BRAF | MAPK | 50 | uM | 11939.161 | 0.3578 | 0.0732 | 1.6513 | |
| 184A1 | NM | Basal | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 5894.098 | 0.9921 | 0.9904 | 1.6523 | |
| 184A1 | NM | Basal | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 5894.098 | 1.0262 | 1.0316 | 1.6523 | |
| 184A1 | NM | Basal | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 5894.098 | 1.0225 | 1.0272 | 1.6523 | |
| 184A1 | NM | Basal | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 5894.098 | 1.0357 | 1.0429 | 1.6523 | |
| 184A1 | NM | Basal | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 5894.098 | 1.0139 | 1.0168 | 1.6523 | |
| 184A1 | NM | Basal | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 5894.098 | 0.9751 | 0.9697 | 1.6523 | |
| 184A1 | NM | Basal | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 5894.098 | 0.9350 | 0.9203 | 1.6523 | |
| 184A1 | NM | Basal | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 5894.098 | 0.4653 | 0.2588 | 1.6523 | |
| 184A1 | NM | Basal | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 5894.098 | 0.3610 | 0.0794 | 1.6523 | |
| 184A1 | NM | Basal | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 5895.098 | 1.1087 | 1.1525 | 1.4041 | |
| 184A1 | NM | Basal | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 5895.098 | 1.0470 | 1.0665 | 1.4041 | |
| 184A1 | NM | Basal | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 5895.098 | 1.0770 | 1.1085 | 1.4041 | |
| 184A1 | NM | Basal | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 5895.098 | 1.0756 | 1.1066 | 1.4041 | |
| 184A1 | NM | Basal | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 5895.098 | 1.0840 | 1.1183 | 1.4041 | |
| 184A1 | NM | Basal | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 5895.098 | 1.0775 | 1.1092 | 1.4041 | |
| 184A1 | NM | Basal | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 5895.098 | 0.9766 | 0.9665 | 1.4041 | |
| 184A1 | NM | Basal | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 5895.098 | 0.5074 | 0.2337 | 1.4041 | |
| 184A1 | NM | Basal | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 5895.098 | 0.7948 | 0.6982 | 1.4041 | |
| 184B5 | NM | Basal | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 5896.098 | 0.9623 | 0.9526 | 1.6038 | |
| 184B5 | NM | Basal | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 5896.098 | 0.9687 | 0.9607 | 1.6038 | |
| 184B5 | NM | Basal | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 5896.098 | 0.9903 | 0.9879 | 1.6038 |