Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-175-VII | HR+ | Luminal | L-779450 | BRAF | MAPK | 10 | uM | 12126.161 | 0.8283 | 0.4779 | 0.6227 | |
| MDA-MB-175-VII | HR+ | Luminal | L-779450 | BRAF | MAPK | 50 | uM | 12126.161 | 0.2863 | -0.7317 | 0.6227 | |
| MDA-MB-361 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.0000853 | uM | 10643.137 | 1.0639 | 1.2010 | 0.6468 | |
| MDA-MB-361 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.000427 | uM | 10643.137 | 1.0355 | 1.1107 | 0.6468 | |
| MDA-MB-361 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.00213 | uM | 10643.137 | 1.0156 | 1.0485 | 0.6468 | |
| MDA-MB-361 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.0107 | uM | 10643.137 | 1.0159 | 1.0495 | 0.6468 | |
| MDA-MB-361 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.0533 | uM | 10643.137 | 1.0927 | 1.2937 | 0.6468 | |
| MDA-MB-361 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.267 | uM | 10643.137 | 1.0119 | 1.0370 | 0.6468 | |
| MDA-MB-361 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 1.33 | uM | 10643.137 | 1.0570 | 1.1790 | 0.6468 | |
| MDA-MB-361 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 6.67 | uM | 10643.137 | 0.9965 | 0.9893 | 0.6468 | |
| MDA-MB-361 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 33.3 | uM | 10643.137 | 0.6238 | -0.0358 | 0.6468 | |
| MDA-MB-361 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.0000853 | uM | 10999.149 | 1.0431 | 1.1195 | 0.7265 | |
| MDA-MB-361 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.000427 | uM | 10999.149 | 0.9705 | 0.9192 | 0.7265 | |
| MDA-MB-361 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.00213 | uM | 10999.149 | 1.0618 | 1.1722 | 0.7265 | |
| MDA-MB-361 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.0107 | uM | 10999.149 | 1.0266 | 1.0737 | 0.7265 | |
| MDA-MB-361 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.0533 | uM | 10999.149 | 0.9893 | 0.9707 | 0.7265 | |
| MDA-MB-361 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.267 | uM | 10999.149 | 1.0624 | 1.1737 | 0.7265 | |
| MDA-MB-361 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 1.33 | uM | 10999.149 | 0.9433 | 0.8456 | 0.7265 | |
| MDA-MB-361 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 6.67 | uM | 10999.149 | 1.0157 | 1.0433 | 0.7265 | |
| MDA-MB-361 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 33.3 | uM | 10999.149 | 0.8434 | 0.5820 | 0.7265 | |
| MDA-MB-415 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0000853 | uM | 10938.149 | 0.9459 | 0.8918 | 1.0006 | |
| MDA-MB-415 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.000427 | uM | 10938.149 | 0.8890 | 0.7782 | 1.0006 | |
| MDA-MB-415 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.00213 | uM | 10938.149 | 0.9886 | 0.9772 | 1.0006 | |
| MDA-MB-415 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0107 | uM | 10938.149 | 0.9310 | 0.8621 | 1.0006 | |
| MDA-MB-415 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0533 | uM | 10938.149 | 0.9337 | 0.8674 | 1.0006 |