Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-415 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.267 | uM | 10938.149 | 0.9660 | 0.9321 | 1.0006 | |
| MDA-MB-415 | HR+ | Luminal | L-779450 | BRAF | MAPK | 1.33 | uM | 10938.149 | 0.5905 | 0.1813 | 1.0006 | |
| MDA-MB-415 | HR+ | Luminal | L-779450 | BRAF | MAPK | 6.67 | uM | 10938.149 | 0.9281 | 0.8564 | 1.0006 | |
| MDA-MB-415 | HR+ | Luminal | L-779450 | BRAF | MAPK | 33.3 | uM | 10938.149 | 0.8658 | 0.7318 | 1.0006 | |
| MDA-MB-415 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0000853 | uM | 12333.166 | 1.0022 | 1.0071 | 0.6353 | |
| MDA-MB-415 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.000427 | uM | 12333.166 | 0.9436 | 0.8254 | 0.6353 | |
| MDA-MB-415 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.00213 | uM | 12333.166 | 1.0376 | 1.1196 | 0.6353 | |
| MDA-MB-415 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0107 | uM | 12333.166 | 0.9497 | 0.8438 | 0.6353 | |
| MDA-MB-415 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0533 | uM | 12333.166 | 0.9377 | 0.8073 | 0.6353 | |
| MDA-MB-415 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.267 | uM | 12333.166 | 0.9646 | 0.8896 | 0.6353 | |
| MDA-MB-415 | HR+ | Luminal | L-779450 | BRAF | MAPK | 1.33 | uM | 12333.166 | 0.9028 | 0.7025 | 0.6353 | |
| MDA-MB-415 | HR+ | Luminal | L-779450 | BRAF | MAPK | 6.67 | uM | 12333.166 | 0.9517 | 0.8501 | 0.6353 | |
| MDA-MB-415 | HR+ | Luminal | L-779450 | BRAF | MAPK | 33.3 | uM | 12333.166 | 0.6557 | 0.0293 | 0.6353 | |
| MDA-MB-453 | TNBC | Luminal | L-779450 | BRAF | MAPK | 0.0000853 | uM | 12414.166 | 1.0111 | 1.0169 | 1.3106 | |
| MDA-MB-453 | TNBC | Luminal | L-779450 | BRAF | MAPK | 0.000427 | uM | 12414.166 | 0.9543 | 0.9298 | 1.3106 | |
| MDA-MB-453 | TNBC | Luminal | L-779450 | BRAF | MAPK | 0.00213 | uM | 12414.166 | 0.9635 | 0.9440 | 1.3106 | |
| MDA-MB-453 | TNBC | Luminal | L-779450 | BRAF | MAPK | 0.0107 | uM | 12414.166 | 0.9196 | 0.8761 | 1.3106 | |
| MDA-MB-453 | TNBC | Luminal | L-779450 | BRAF | MAPK | 0.0533 | uM | 12414.166 | 0.9376 | 0.9040 | 1.3106 | |
| MDA-MB-453 | TNBC | Luminal | L-779450 | BRAF | MAPK | 0.267 | uM | 12414.166 | 0.9551 | 0.9312 | 1.3106 | |
| MDA-MB-453 | TNBC | Luminal | L-779450 | BRAF | MAPK | 1.33 | uM | 12414.166 | 0.9167 | 0.8716 | 1.3106 | |
| MDA-MB-453 | TNBC | Luminal | L-779450 | BRAF | MAPK | 6.67 | uM | 12414.166 | 0.9064 | 0.8555 | 1.3106 | |
| MDA-MB-453 | TNBC | Luminal | L-779450 | BRAF | MAPK | 33.3 | uM | 12414.166 | 0.7673 | 0.6341 | 1.3106 | |
| MX1 | Unknown | Unknown | L-779450 | BRAF | MAPK | 0.0000853 | uM | 10644.137 | 1.0647 | 1.2271 | 0.5827 | |
| MX1 | Unknown | Unknown | L-779450 | BRAF | MAPK | 0.000427 | uM | 10644.137 | 0.9269 | 0.7558 | 0.5827 | |
| MX1 | Unknown | Unknown | L-779450 | BRAF | MAPK | 0.00213 | uM | 10644.137 | 1.0159 | 1.0549 | 0.5827 |