Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1937 | TNBC | Basal A | L-779450 | BRAF | MAPK | 10 | uM | 11849.161 | 1.0629 | 1.0979 | 1.2764 | |
| HCC1937 | TNBC | Basal A | L-779450 | BRAF | MAPK | 50 | uM | 11849.161 | 0.1284 | -0.5996 | 1.2764 | |
| HCC1954 | HER2amp | Basal A | L-779450 | BRAF | MAPK | 0.0000853 | uM | 11055.149 | 0.9873 | 0.9848 | 1.6723 | |
| HCC1954 | HER2amp | Basal A | L-779450 | BRAF | MAPK | 0.000427 | uM | 11055.149 | 0.9492 | 0.9386 | 1.6723 | |
| HCC1954 | HER2amp | Basal A | L-779450 | BRAF | MAPK | 0.00213 | uM | 11055.149 | 0.9871 | 0.9845 | 1.6723 | |
| HCC1954 | HER2amp | Basal A | L-779450 | BRAF | MAPK | 0.0107 | uM | 11055.149 | 0.9766 | 0.9719 | 1.6723 | |
| HCC1954 | HER2amp | Basal A | L-779450 | BRAF | MAPK | 0.0533 | uM | 11055.149 | 0.9765 | 0.9717 | 1.6723 | |
| HCC1954 | HER2amp | Basal A | L-779450 | BRAF | MAPK | 0.267 | uM | 11055.149 | 1.0449 | 1.0532 | 1.6723 | |
| HCC1954 | HER2amp | Basal A | L-779450 | BRAF | MAPK | 1.33 | uM | 11055.149 | 0.9525 | 0.9426 | 1.6723 | |
| HCC1954 | HER2amp | Basal A | L-779450 | BRAF | MAPK | 6.67 | uM | 11055.149 | 0.9841 | 0.9809 | 1.6723 | |
| HCC1954 | HER2amp | Basal A | L-779450 | BRAF | MAPK | 33.3 | uM | 11055.149 | 0.7075 | 0.6261 | 1.6723 | |
| HCC2185 | TNBC | Luminal | L-779450 | BRAF | MAPK | 0.0000853 | uM | 10996.149 | 0.9912 | 0.9631 | 0.4765 | |
| HCC2185 | TNBC | Luminal | L-779450 | BRAF | MAPK | 0.000427 | uM | 10996.149 | 1.0744 | 1.3250 | 0.4765 | |
| HCC2185 | TNBC | Luminal | L-779450 | BRAF | MAPK | 0.00213 | uM | 10996.149 | 0.9990 | 0.9956 | 0.4765 | |
| HCC2185 | TNBC | Luminal | L-779450 | BRAF | MAPK | 0.0107 | uM | 10996.149 | 1.1075 | 1.4781 | 0.4765 | |
| HCC2185 | TNBC | Luminal | L-779450 | BRAF | MAPK | 0.0533 | uM | 10996.149 | 1.0021 | 1.0088 | 0.4765 | |
| HCC2185 | TNBC | Luminal | L-779450 | BRAF | MAPK | 0.267 | uM | 10996.149 | 0.9759 | 0.9000 | 0.4765 | |
| HCC2185 | TNBC | Luminal | L-779450 | BRAF | MAPK | 1.33 | uM | 10996.149 | 0.8993 | 0.6005 | 0.4765 | |
| HCC2185 | TNBC | Luminal | L-779450 | BRAF | MAPK | 6.67 | uM | 10996.149 | 1.0495 | 1.2134 | 0.4765 | |
| HCC2185 | TNBC | Luminal | L-779450 | BRAF | MAPK | 33.3 | uM | 10996.149 | 0.9034 | 0.6160 | 0.4765 | |
| HCC2185 | TNBC | Luminal | L-779450 | BRAF | MAPK | 0.000128 | uM | 12192.161 | 1.0016 | 1.0059 | 0.5555 | |
| HCC2185 | TNBC | Luminal | L-779450 | BRAF | MAPK | 0.00064 | uM | 12192.161 | 0.9947 | 0.9811 | 0.5555 | |
| HCC2185 | TNBC | Luminal | L-779450 | BRAF | MAPK | 0.0032 | uM | 12192.161 | 1.0943 | 1.3522 | 0.5555 | |
| HCC2185 | TNBC | Luminal | L-779450 | BRAF | MAPK | 0.016 | uM | 12192.161 | 1.1928 | 1.7468 | 0.5555 | |
| HCC2185 | TNBC | Luminal | L-779450 | BRAF | MAPK | 0.08 | uM | 12192.161 | 1.1048 | 1.3930 | 0.5555 |