Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1569 | HER2amp | Basal A | L-779450 | BRAF | MAPK | 0.0000853 | uM | 12523.166 | 0.9563 | 0.9120 | 0.9938 | |
| HCC1569 | HER2amp | Basal A | L-779450 | BRAF | MAPK | 0.000427 | uM | 12523.166 | 0.9158 | 0.8306 | 0.9938 | |
| HCC1569 | HER2amp | Basal A | L-779450 | BRAF | MAPK | 0.00213 | uM | 12523.166 | 0.9960 | 0.9919 | 0.9938 | |
| HCC1569 | HER2amp | Basal A | L-779450 | BRAF | MAPK | 0.0107 | uM | 12523.166 | 0.9966 | 0.9932 | 0.9938 | |
| HCC1569 | HER2amp | Basal A | L-779450 | BRAF | MAPK | 0.0533 | uM | 12523.166 | 0.9729 | 0.9455 | 0.9938 | |
| HCC1569 | HER2amp | Basal A | L-779450 | BRAF | MAPK | 0.267 | uM | 12523.166 | 0.9825 | 0.9647 | 0.9938 | |
| HCC1569 | HER2amp | Basal A | L-779450 | BRAF | MAPK | 1.33 | uM | 12523.166 | 0.9729 | 0.9455 | 0.9938 | |
| HCC1569 | HER2amp | Basal A | L-779450 | BRAF | MAPK | 6.67 | uM | 12523.166 | 0.8786 | 0.7558 | 0.9938 | |
| HCC1569 | HER2amp | Basal A | L-779450 | BRAF | MAPK | 33.3 | uM | 12523.166 | 0.6799 | 0.3565 | 0.9938 | |
| HCC1806 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.000128 | uM | 12239.161 | 1.0691 | 1.0751 | 1.8129 | |
| HCC1806 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.00064 | uM | 12239.161 | 0.9839 | 0.9821 | 1.8129 | |
| HCC1806 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.0032 | uM | 12239.161 | 1.0283 | 1.0310 | 1.8129 | |
| HCC1806 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.016 | uM | 12239.161 | 1.1091 | 1.1176 | 1.8129 | |
| HCC1806 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.08 | uM | 12239.161 | 1.0449 | 1.0490 | 1.8129 | |
| HCC1806 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.4 | uM | 12239.161 | 1.0406 | 1.0444 | 1.8129 | |
| HCC1806 | TNBC | Basal A | L-779450 | BRAF | MAPK | 2 | uM | 12239.161 | 0.9626 | 0.9584 | 1.8129 | |
| HCC1806 | TNBC | Basal A | L-779450 | BRAF | MAPK | 10 | uM | 12239.161 | 0.7480 | 0.7040 | 1.8129 | |
| HCC1806 | TNBC | Basal A | L-779450 | BRAF | MAPK | 50 | uM | 12239.161 | 0.0199 | -0.7694 | 1.8129 | |
| HCC1937 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.000128 | uM | 11849.161 | 1.0464 | 1.0723 | 1.2764 | |
| HCC1937 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.00064 | uM | 11849.161 | 1.0559 | 1.0870 | 1.2764 | |
| HCC1937 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.0032 | uM | 11849.161 | 1.1388 | 1.2143 | 1.2764 | |
| HCC1937 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.016 | uM | 11849.161 | 1.1650 | 1.2542 | 1.2764 | |
| HCC1937 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.08 | uM | 11849.161 | 1.1392 | 1.2150 | 1.2764 | |
| HCC1937 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.4 | uM | 11849.161 | 1.2424 | 1.3708 | 1.2764 | |
| HCC1937 | TNBC | Basal A | L-779450 | BRAF | MAPK | 2 | uM | 11849.161 | 1.1169 | 1.1810 | 1.2764 |