Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM225CWN | HER2amp | Basal A | L-779450 | BRAF | MAPK | 0.08 | uM | 12098.161 | 1.0224 | 1.0315 | 1.4196 | |
| SUM225CWN | HER2amp | Basal A | L-779450 | BRAF | MAPK | 0.4 | uM | 12098.161 | 1.1075 | 1.1491 | 1.4196 | |
| SUM225CWN | HER2amp | Basal A | L-779450 | BRAF | MAPK | 2 | uM | 12098.161 | 0.8169 | 0.7344 | 1.4196 | |
| SUM225CWN | HER2amp | Basal A | L-779450 | BRAF | MAPK | 10 | uM | 12098.161 | 0.6376 | 0.4567 | 1.4196 | |
| SUM225CWN | HER2amp | Basal A | L-779450 | BRAF | MAPK | 50 | uM | 12098.161 | 0.2044 | -0.3465 | 1.4196 | |
| SUM229PE | TNBC | - | L-779450 | BRAF | MAPK | 0.0000853 | uM | 11058.149 | 1.0042 | 1.0038 | 2.1834 | |
| SUM229PE | TNBC | - | L-779450 | BRAF | MAPK | 0.000427 | uM | 11058.149 | 0.9969 | 0.9971 | 2.1834 | |
| SUM229PE | TNBC | - | L-779450 | BRAF | MAPK | 0.00213 | uM | 11058.149 | 1.0096 | 1.0088 | 2.1834 | |
| SUM229PE | TNBC | - | L-779450 | BRAF | MAPK | 0.0107 | uM | 11058.149 | 1.0776 | 1.0696 | 2.1834 | |
| SUM229PE | TNBC | - | L-779450 | BRAF | MAPK | 0.0533 | uM | 11058.149 | 0.9909 | 0.9917 | 2.1834 | |
| SUM229PE | TNBC | - | L-779450 | BRAF | MAPK | 0.267 | uM | 11058.149 | 0.9447 | 0.9485 | 2.1834 | |
| SUM229PE | TNBC | - | L-779450 | BRAF | MAPK | 1.33 | uM | 11058.149 | 0.9349 | 0.9393 | 2.1834 | |
| SUM229PE | TNBC | - | L-779450 | BRAF | MAPK | 6.67 | uM | 11058.149 | 1.1564 | 1.1377 | 2.1834 | |
| SUM229PE | TNBC | - | L-779450 | BRAF | MAPK | 33.3 | uM | 11058.149 | 0.3779 | 0.2808 | 2.1834 | |
| SUM52PE | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0000853 | uM | 10695.149 | 0.9851 | 0.9775 | 1.3252 | |
| SUM52PE | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.000427 | uM | 10695.149 | 1.0105 | 1.0159 | 1.3252 | |
| SUM52PE | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.00213 | uM | 10695.149 | 0.9230 | 0.8827 | 1.3252 | |
| SUM52PE | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0107 | uM | 10695.149 | 1.0163 | 1.0246 | 1.3252 | |
| SUM52PE | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0533 | uM | 10695.149 | 0.9534 | 0.9292 | 1.3252 | |
| SUM52PE | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.267 | uM | 10695.149 | 0.9932 | 0.9898 | 1.3252 | |
| SUM52PE | HR+ | Luminal | L-779450 | BRAF | MAPK | 1.33 | uM | 10695.149 | 0.8018 | 0.6930 | 1.3252 | |
| SUM52PE | HR+ | Luminal | L-779450 | BRAF | MAPK | 6.67 | uM | 10695.149 | 0.7593 | 0.6247 | 1.3252 | |
| SUM52PE | HR+ | Luminal | L-779450 | BRAF | MAPK | 33.3 | uM | 10695.149 | 0.0881 | -0.6803 | 1.3252 | |
| SUM52PE | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.000128 | uM | 11852.161 | 0.9317 | 0.9118 | 1.5680 | |
| SUM52PE | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.00064 | uM | 11852.161 | 0.9359 | 0.9173 | 1.5680 |