Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM159PT | TNBC | Basal B | L-779450 | BRAF | MAPK | 1.33 | uM | 10520.137 | 0.8541 | 0.9183 | 3.7823 | |
| SUM159PT | TNBC | Basal B | L-779450 | BRAF | MAPK | 6.67 | uM | 10520.137 | 0.7354 | 0.8439 | 3.7823 | |
| SUM159PT | TNBC | Basal B | L-779450 | BRAF | MAPK | 33.3 | uM | 10520.137 | 0.1510 | 0.2133 | 3.7823 | |
| SUM159PT | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.0000853 | uM | 11057.149 | 0.9918 | 0.9960 | 4.1019 | |
| SUM159PT | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.000427 | uM | 11057.149 | 0.9909 | 0.9956 | 4.1019 | |
| SUM159PT | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.00213 | uM | 11057.149 | 0.9618 | 0.9811 | 4.1019 | |
| SUM159PT | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.0107 | uM | 11057.149 | 1.0823 | 1.0389 | 4.1019 | |
| SUM159PT | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.0533 | uM | 11057.149 | 1.1563 | 1.0721 | 4.1019 | |
| SUM159PT | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.267 | uM | 11057.149 | 1.0206 | 1.0100 | 4.1019 | |
| SUM159PT | TNBC | Basal B | L-779450 | BRAF | MAPK | 1.33 | uM | 11057.149 | 0.9308 | 0.9653 | 4.1019 | |
| SUM159PT | TNBC | Basal B | L-779450 | BRAF | MAPK | 6.67 | uM | 11057.149 | 0.9228 | 0.9612 | 4.1019 | |
| SUM159PT | TNBC | Basal B | L-779450 | BRAF | MAPK | 33.3 | uM | 11057.149 | 0.2383 | 0.4099 | 4.1019 | |
| SUM225CWN | HER2amp | Basal A | L-779450 | BRAF | MAPK | 0.0000853 | uM | 10579.137 | 1.0090 | 1.0196 | 0.9202 | |
| SUM225CWN | HER2amp | Basal A | L-779450 | BRAF | MAPK | 0.000427 | uM | 10579.137 | 0.9491 | 0.8895 | 0.9202 | |
| SUM225CWN | HER2amp | Basal A | L-779450 | BRAF | MAPK | 0.00213 | uM | 10579.137 | 1.0421 | 1.0917 | 0.9202 | |
| SUM225CWN | HER2amp | Basal A | L-779450 | BRAF | MAPK | 0.0107 | uM | 10579.137 | 0.9836 | 0.9645 | 0.9202 | |
| SUM225CWN | HER2amp | Basal A | L-779450 | BRAF | MAPK | 0.0533 | uM | 10579.137 | 1.0402 | 1.0875 | 0.9202 | |
| SUM225CWN | HER2amp | Basal A | L-779450 | BRAF | MAPK | 0.267 | uM | 10579.137 | 1.0211 | 1.0459 | 0.9202 | |
| SUM225CWN | HER2amp | Basal A | L-779450 | BRAF | MAPK | 1.33 | uM | 10579.137 | 1.0249 | 1.0541 | 0.9202 | |
| SUM225CWN | HER2amp | Basal A | L-779450 | BRAF | MAPK | 6.67 | uM | 10579.137 | 0.7845 | 0.5363 | 0.9202 | |
| SUM225CWN | HER2amp | Basal A | L-779450 | BRAF | MAPK | 33.3 | uM | 10579.137 | 0.4118 | -0.2373 | 0.9202 | |
| SUM225CWN | HER2amp | Basal A | L-779450 | BRAF | MAPK | 0.000128 | uM | 12098.161 | 1.0350 | 1.0490 | 1.4196 | |
| SUM225CWN | HER2amp | Basal A | L-779450 | BRAF | MAPK | 0.00064 | uM | 12098.161 | 0.9943 | 0.9919 | 1.4196 | |
| SUM225CWN | HER2amp | Basal A | L-779450 | BRAF | MAPK | 0.0032 | uM | 12098.161 | 1.0568 | 1.0793 | 1.4196 | |
| SUM225CWN | HER2amp | Basal A | L-779450 | BRAF | MAPK | 0.016 | uM | 12098.161 | 1.1092 | 1.1514 | 1.4196 |