Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM52PE | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0032 | uM | 11852.161 | 1.0186 | 1.0237 | 1.5680 | |
| SUM52PE | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.016 | uM | 11852.161 | 0.9182 | 0.8941 | 1.5680 | |
| SUM52PE | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.08 | uM | 11852.161 | 0.9373 | 0.9191 | 1.5680 | |
| SUM52PE | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.4 | uM | 11852.161 | 0.8455 | 0.7971 | 1.5680 | |
| SUM52PE | HR+ | Luminal | L-779450 | BRAF | MAPK | 2 | uM | 11852.161 | 0.8774 | 0.8400 | 1.5680 | |
| SUM52PE | HR+ | Luminal | L-779450 | BRAF | MAPK | 10 | uM | 11852.161 | 0.6024 | 0.4476 | 1.5680 | |
| SUM52PE | HR+ | Luminal | L-779450 | BRAF | MAPK | 50 | uM | 11852.161 | 0.0253 | -0.8083 | 1.5680 | |
| T47D | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0000853 | uM | 10939.149 | 0.9884 | 0.9861 | 1.6748 | |
| T47D | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.000427 | uM | 10939.149 | 1.0038 | 1.0045 | 1.6748 | |
| T47D | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.00213 | uM | 10939.149 | 1.0198 | 1.0236 | 1.6748 | |
| T47D | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0107 | uM | 10939.149 | 1.0097 | 1.0115 | 1.6748 | |
| T47D | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0533 | uM | 10939.149 | 0.9824 | 0.9789 | 1.6748 | |
| T47D | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.267 | uM | 10939.149 | 0.9587 | 0.9502 | 1.6748 | |
| T47D | HR+ | Luminal | L-779450 | BRAF | MAPK | 1.33 | uM | 10939.149 | 0.9059 | 0.8854 | 1.6748 | |
| T47D | HR+ | Luminal | L-779450 | BRAF | MAPK | 6.67 | uM | 10939.149 | 0.9741 | 0.9689 | 1.6748 | |
| T47D | HR+ | Luminal | L-779450 | BRAF | MAPK | 33.3 | uM | 10939.149 | 0.7263 | 0.6524 | 1.6748 | |
| T47DKBLUC | Unknown | Unknown | L-779450 | BRAF | MAPK | 0.0000853 | uM | 12608.166 | 0.9682 | 0.9341 | 0.9629 | |
| T47DKBLUC | Unknown | Unknown | L-779450 | BRAF | MAPK | 0.000427 | uM | 12608.166 | 1.0039 | 1.0081 | 0.9629 | |
| T47DKBLUC | Unknown | Unknown | L-779450 | BRAF | MAPK | 0.00213 | uM | 12608.166 | 0.9582 | 0.9133 | 0.9629 | |
| T47DKBLUC | Unknown | Unknown | L-779450 | BRAF | MAPK | 0.0107 | uM | 12608.166 | 1.0293 | 1.0608 | 0.9629 | |
| T47DKBLUC | Unknown | Unknown | L-779450 | BRAF | MAPK | 0.0533 | uM | 12608.166 | 0.9890 | 0.9772 | 0.9629 | |
| T47DKBLUC | Unknown | Unknown | L-779450 | BRAF | MAPK | 0.267 | uM | 12608.166 | 1.0018 | 1.0037 | 0.9629 | |
| T47DKBLUC | Unknown | Unknown | L-779450 | BRAF | MAPK | 1.33 | uM | 12608.166 | 0.9766 | 0.9515 | 0.9629 | |
| T47DKBLUC | Unknown | Unknown | L-779450 | BRAF | MAPK | 6.67 | uM | 12608.166 | 0.9848 | 0.9684 | 0.9629 | |
| T47DKBLUC | Unknown | Unknown | L-779450 | BRAF | MAPK | 33.3 | uM | 12608.166 | 0.7042 | 0.3895 | 0.9629 |