Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1143 | TNBC | Basal A | L-779450 | BRAF | MAPK | 2 | uM | 12112.161 | 0.9009 | 0.8821 | 1.7182 | |
| HCC1143 | TNBC | Basal A | L-779450 | BRAF | MAPK | 10 | uM | 12112.161 | 1.0348 | 1.0402 | 1.7182 | |
| HCC1143 | TNBC | Basal A | L-779450 | BRAF | MAPK | 50 | uM | 12112.161 | 0.2290 | -0.1519 | 1.7182 | |
| HCC1187 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.0000853 | uM | 10518.137 | 1.0817 | 1.1307 | 1.2405 | |
| HCC1187 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.000427 | uM | 10518.137 | 0.9334 | 0.8919 | 1.2405 | |
| HCC1187 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.00213 | uM | 10518.137 | 0.9525 | 0.9230 | 1.2405 | |
| HCC1187 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.0107 | uM | 10518.137 | 1.0076 | 1.0123 | 1.2405 | |
| HCC1187 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.0533 | uM | 10518.137 | 1.0876 | 1.1401 | 1.2405 | |
| HCC1187 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.267 | uM | 10518.137 | 0.9420 | 0.9060 | 1.2405 | |
| HCC1187 | TNBC | Basal A | L-779450 | BRAF | MAPK | 1.33 | uM | 10518.137 | 1.0447 | 1.0718 | 1.2405 | |
| HCC1187 | TNBC | Basal A | L-779450 | BRAF | MAPK | 6.67 | uM | 10518.137 | 0.9073 | 0.8492 | 1.2405 | |
| HCC1187 | TNBC | Basal A | L-779450 | BRAF | MAPK | 33.3 | uM | 10518.137 | 0.6197 | 0.3599 | 1.2405 | |
| HCC1187 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.0000853 | uM | 10753.149 | 0.9921 | 0.9888 | 1.4167 | |
| HCC1187 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.000427 | uM | 10753.149 | 0.9487 | 0.9270 | 1.4167 | |
| HCC1187 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.00213 | uM | 10753.149 | 0.9930 | 0.9901 | 1.4167 | |
| HCC1187 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.0107 | uM | 10753.149 | 0.9369 | 0.9101 | 1.4167 | |
| HCC1187 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.0533 | uM | 10753.149 | 0.9710 | 0.9589 | 1.4167 | |
| HCC1187 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.267 | uM | 10753.149 | 1.0206 | 1.0290 | 1.4167 | |
| HCC1187 | TNBC | Basal A | L-779450 | BRAF | MAPK | 1.33 | uM | 10753.149 | 1.0219 | 1.0308 | 1.4167 | |
| HCC1187 | TNBC | Basal A | L-779450 | BRAF | MAPK | 6.67 | uM | 10753.149 | 0.8945 | 0.8487 | 1.4167 | |
| HCC1187 | TNBC | Basal A | L-779450 | BRAF | MAPK | 33.3 | uM | 10753.149 | 0.4792 | 0.1899 | 1.4167 | |
| HCC1395 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.0000853 | uM | 12000.166 | 1.0074 | 1.0197 | 0.7468 | |
| HCC1395 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.000427 | uM | 12000.166 | 0.9398 | 0.8404 | 0.7468 | |
| HCC1395 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.00213 | uM | 12000.166 | 1.0002 | 1.0006 | 0.7468 | |
| HCC1395 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.0107 | uM | 12000.166 | 0.9247 | 0.8009 | 0.7468 |